[en] The pharmacokinetics of miconazole were studied after intravenous administration to six sheep (4 mg/kg) of three aqueous solutions: a marketed micellar solution containing polyoxyl-35 castor oil (Daktarin IV(R)) was compared with two solutions both containing 50 mM lactic acid and a cyclodextrin derivative (100 mM HP-betaCD or 50 mM SBE7-betaCD). The aim of this work was to demonstrate that these cyclodextrin derivatives (CDs) have no effect on the pharmacokinetics of miconazole by comparison with the micellar solution. The plasma concentration time curves have shown that there is no significant difference between the three solutions.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Piel, Géraldine ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale
Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique
Van Hees, Thierry ; Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique
Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Comparison of the Iv Pharmacokinetics in Sheep of Miconazole-Cyclodextrin Solutions and a Micellar Solution
Bononi, L.J., 1995. Beta-cyclodextrin complexes of miconazole and econazole. US Patent, 5,422,347, June 6.
Brewster M.E., Estes K.S., Bodor N. Development of a non-surfactant formulation for alfaxalone through the use of chemically modified cyclodextrins. J. Parenteral Sci. Technol. 43(6):1989;262-265.
Brewster M.E., Estes K.S., Bodor N. An intravenous toxicity study of hydroxypropyl-β-cyclodextrin, a useful drug solubilizer, in rats and in monkeys. Int. J. Pharm. 59:1990;231-243.
Hopkins C.S. Adverse reaction to a cremophor containing preparation of intravenous vitamin. Intensive Ther. Clin. Monit. 9:1988;254-255.
Hosobuto H. Quantitative determination of miconazole in human serum by high-performance liquid chromatography. Chromatographia. 25(8):1988;717-720.
Howrie D.L., Ptachcinski R.J., Griffith B.P., Hadersty R.J., Venkataramanan R. Anaphylactoid reactions associated with parenteral cyclosporine use: possible role of cremophor EL. Drug Intell. Clin. Pharm. 19:1984;425-427.
Kauffman A., Carver P. Use of azoles for systemic antifungal therapy. Adv. Pharmacol. 39:1997;147-189.
Mura P., Liguori A., Bramanti G., Bettinetti G., Campisi E., Faggi E. Improvement of dissolution properties and microbiological activity of miconazole and econazole by cyclodextrin complexation. Eur. J. Pharm. Biopharm. 38(3):1992;119-123.
Pedersen M., Pedersen S., Sorensen A.M. Polymorphism of miconazole during preparation of solid systems of the drug and β-cyclodextrins. Pharm. Acta Helv. 68:1993;43-47.
Pedersen M., Edelsten M., Nielsen V.F., Scarpellini A., Skytte S., Slot C. Formation and antimycotic effect of cyclodextrin inclusion complexes of econazole and miconazole. Int. J. Pharm. 90:1993;247-254.
Perdersen M. Isolation and antimycotic effect of a genuine miconazole β-cyclodextrin complex. Eur. J. Pharm. Biopharm. 40(1):1994;19-23.
Piel G., Evrard B., Delattre L. Complexes à multicomposants de miconazole avec différents acides et cyclodextrines. J. Pharm. Belg. 52(3):1997;124.
Piel G., Evrard B., Fillet M., Llabres G., Delattre L. Development of a non-surfactant parenteral formulation of miconazole by the use of cyclodextrins. Int. J. Pharm. 169:1998;15-22.
Reynolds D.J., Aronson J.K. Selected side effects Part 8. Anaphylactoid reaction to intravenous vitamin K. Prescribers' J. 32(4):1992;167-170.
Stella, V.J., 1996. SBE7-βCD, a new novel and safe polyanionic β-CD derivative: characterization and biomedical applications. Proc. 8th Int. Symp. on CD, Budapest, Hungary, March 31-April 2, pp. 471-476. Kluwer Academic Publishers, Dordrecht, Netherland, Ed. J. Szejtli.
Van Doorne H., Bosch E.H., Lerk C.F. Formation and antimicrobial activity of complexes of β-cyclodextrin and some antimycotic imidazole derivatives. Pharm. Weekblad. 10:1988;80-85.
Van Doorne, H., Bosch, E.H. and Lerk, C.F., 1988b. Interactions between cyclodextrins and some antimycotic imidazole derivatives: studies on solubility and antimicrobial activity. Proc. 4th Int. Symp. Cyclodextrins, Munich, West Germany, April 20-22, pp. 285-291. Kluwer Academic Publishers, Dordrecht, Netherland, Ed. O. Huber and J. Szejtli.
Yoshida A. Pharmaceutical evaluation of hydroxyalkylethers of β-cyclodextrin. Int. J. Pharm. 46:1988;217-222.