Comparison of the Iv Pharmacokinetics in Sheep of Miconazole-Cyclodextrin Solutions and a Micellar Solution

[en] The pharmacokinetics of miconazole were studied after intravenous administration to six sheep (4 mg/kg) of three aqueous solutions: a marketed micellar solution containing polyoxyl-35 castor oil (Daktarin IV(R)) was compared with two solutions both containing 50 mM lactic acid and a cyclodextrin derivative (100 mM HP-betaCD or 50 mM SBE7-betaCD). The aim of this work was to demonstrate that these cyclodextrin derivatives (CDs) have no effect on the pharmacokinetics of miconazole by comparison with the micellar solution. The plasma concentration time curves have shown that there is no significant difference between the three solutions.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Piel, Géraldine ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique et magistrale

Evrard, Brigitte ; Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique

Van Hees, Thierry ; Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique

Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Language :

English

Title :

Comparison of the Iv Pharmacokinetics in Sheep of Miconazole-Cyclodextrin Solutions and a Micellar Solution

Publication date :

25 March 1999

Journal title :

International Journal of Pharmaceutics

ISSN :

0378-5173

eISSN :

1873-3476

Publisher :

Elsevier

Volume :

180

Issue :

Pages :

41-5

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 12 August 2009

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Bibliography

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