Article (Scientific journals)
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Garcia-Gonzalo, F. R.; Phua, S. C.; Roberson, E. C. et al.
2015In Developmental Cell, 34, p. 400-409
Peer Reviewed verified by ORBi
 

Files


Full Text
Garcia-Gonzalo et al DevCell pdf final.pdf
Publisher postprint (3.19 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
primary cilium; phosphoinositides; Inpp5e
Abstract :
[en] Primary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for signaling is unclear. One possibility is that some forms of signaling require a distinct membrane lipid composition, found at cilia. We found that the ciliary membrane contains a particular phosphoinositide, PI(4)P, whereas a different phosphoinositide, PI(4,5)P2, is restricted to the membrane of the ciliary base. This distribution is created by Inpp5e, a ciliary phosphoinositide 5-phosphatase. Without Inpp5e, ciliary PI(4,5)P2 levels are elevated and Hh signaling is disrupted. Inpp5e limits the ciliary level s of inhibitors of Hh signaling, including Gpr161 and the PI(4,5)2-binding protein Tulp3. Increasing ciliary PI(4,5)P2levels or conferring the ability to bind PI(4)P on Tulp3 increases the ciliary localization of Tulp3. Lowering Tulp3 in cells lacking Inpp5e
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Garcia-Gonzalo, F. R.
Phua, S. C.
Roberson, E. C.
Garcia III, G.
Abedin, M.
Schurmans, Stéphane  ;  Université de Liège > Département de sciences fonctionnelles (DSF) > Biochimie métabolique vétérinaire
Inoue, T
Reiter, J. F.
Language :
English
Title :
Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.
Publication date :
2015
Journal title :
Developmental Cell
ISSN :
1534-5807
Publisher :
Elsevier Science
Volume :
34
Pages :
400-409
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 August 2015

Statistics


Number of views
85 (7 by ULiège)
Number of downloads
152 (1 by ULiège)

Scopus citations®
 
218
Scopus citations®
without self-citations
196
OpenCitations
 
252

Bibliography


Similar publications



Contact ORBi