Dexamethasone Bovine Pharmacokinetics

[en] Dexamethasone phosphate (DXM-PHO) is an ester which is quickly hydrolysed by the bovine and the dexamethasone (DXM) plasma half-life was 5.16 h. It has been demonstrated that 54 h after DXM-PHO injection, DXM concentrations were lower than 0.1 mglml. Tritiated dexamethasone was also administered twice to an another young bull for metabolite investigation. The elapsed time required to recover, in plasma, half of the radioactivity injected was 8.8 h. Radioactivity recovery in the urine reached 36.4% and 22.6% for the first and the second injections respectively.

Disciplines :

Agriculture & agronomy

Author, co-author :

Gaignage, P.

Lognay, Georges ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Bosson, D.

Vertongen, D.

Dreze, P.

Marlier, M.

Severin, M.

Language :

English

Title :

Dexamethasone Bovine Pharmacokinetics

Publication date :

1991

Journal title :

European Journal of Drug Metabolism and Pharmacokinetics

ISSN :

0378-7966

Publisher :

Adis

Volume :

Issue :

Pages :

219-221
219-221

Peer reviewed :

Peer reviewed

Additional URL :

http://link.springer.com/journal/13318/16/3/page/1

Available on ORBi :

since 24 August 2015

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Bibliography

Lognay G., Marlier M., Renaville R., Severin M. (1987) Sequential analysis of preparations promoting the zootechnical performances in cattle. Rec. Med. Vet 163:655-660.
Gaignage, Lognay G., Marlier M., Severin M., Dreze (1989) Applications of chromatographic and spectrometric techniques to the study of dexamethasone related compounds. Chromatographia 28:623-630.
Lejeune-Lenain C., Kina S., Bosson D. (1987) Preparative HPLC for analysis of mineralocorticoids in human plasma. Chromatographia 24:333-338.
Fairclough R.J., Hunter J.T., Welch R.A.S. (1981) Dexamethasone concentrations in plasma and milk of cows following the injection of long and short acting dexamethasone esters. Aust. J. Biol. Sci. 34:313-319.
Tainturier D., Alvinerie M., Brandon R.A., Toutain P.L. (1981) Dexamethasone concentrations in bovine blood plasma and milk after intravenous injection. J. Dairy Sei. 65:1921-1924.
Toutain P.L., Brandon R.A., Alvinerie M., Garcia-Villar R., Ruchebusch Y. (1982) Dexamethasone in cattle: pharmacokinetics and action on the adrenal gland. J. Vet Pharmacol. Therap. 5:33-43.