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Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects?

Lehnert, Kristina; Ronnenberg, Katrin; Weijs, Liesbeth et al.

2016 • In Archives of Environmental Contamination and Toxicology, 70 (1), p. 106-120

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/185212

DOI
10.1007/s00244-015-0202-3

PubMed
26296438

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Keywords :

marine mammals; seals; pollutants; biomarkers; Phoca vitulina

Abstract :

[en] Harbor seals are exposed to increasing pressure caused by anthropogenic activities in their marine environment. Persistent organic pollutants (POPs) and trace elements are hazardous contaminants which accumulate in tissues of harbor seals. POPs and trace elements can negatively affect the immune-system and have been reported e.g. to increase susceptibility to viral infections in seals. Biomarkers of the xenobiotic metabolism, cytokines and heat-shock-protein as cell mediators of the immune-system were established to evaluate the impact of environmental stressors on harbor seals. Harbor seals (n=54) were captured on sandbanks in the North Sea during 2009 to 2012. Medicals including hematology were performed, RNAlater blood samples were taken and analyzed using quantitative Polymerase Chain Reaction. Normalized transcript copy numbers were correlated to hematology and POP concentration in blood, and trace metals in blood and fur.

Research Center/Unit :

MARE - Centre Interfacultaire de Recherches en Océanologie - ULiège

Disciplines :

Environmental sciences & ecology
Anatomy (cytology, histology, embryology...) & physiology
Aquatic sciences & oceanology

Author, co-author :

Lehnert, Kristina

Ronnenberg, Katrin

Weijs, Liesbeth

Covaci, Adrian

Das, Krishna ; Université de Liège > Département de Biologie, Ecologie et Evolution > Océanologie

Hellwig, Veronika

Siebert, Ursula

Language :

English

Title :

Xenobiotic and Immune-Relevant Molecular Biomarkers in Harbor Seals as Proxies for Pollutant Burden and Effects?

Publication date :

January 2016

Journal title :

Archives of Environmental Contamination and Toxicology

ISSN :

0090-4341

eISSN :

1432-0703

Publisher :

Springer Science & Business Media B.V., New York, United States - New York

Volume :

70

Issue :

1

Pages :

106-120

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 24 August 2015

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5 (4 by ULiège)

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Scopus citations^®

21

Scopus citations^®
without self-citations

8

OpenCitations

15

OpenAlex citations

23

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