Cancer du sein : de la thérapie ciblée à la médecine personnalisée

oncologie; cancer du sein; traitement systémique; médecine personnalisée; traitement ciblé; chimiothérapie; hormonothérapie; oncology; breast cancer; systemic therapy; precision medicine; targeted therapy; chemotherapy; endocrine therapy

Abstract :

[fr] Dans cet article, les auteurs passent en revue les grands principes de prise en charge du traitement systémique du cancer du sein et posent la question suivante : jusqu'où réellement aujourd'hui ce traitement est-il individualisé ? Les nouvelles technologies permettent une analyse détaillée des anomalies génomiques au niveau des cellules cancéreuses. Malheureusement, nous n'avons pas encore compris comment utiliser au mieux ces données au bénéfice du patient. La majorité des modifications du génome sont des évènements relativement rares compliquant le développement de nouveaux médicaments dans le cadre d'une médecine de précision. De plus, les tumeurs présentent une grande hétérogénéité temporelle et spatiale dont il faudra tenir compte lors de ce développement. Une collaboration internationale intensive est en cours pour tenter de confirmer que la médecine de précision permet d'optimiser les résultats du traitement systémique dans le cancer du sein.

Disciplines :

Oncology

Author, co-author :

JERUSALEM, Guy ; Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale

COLLIGNON, Joëlle ; Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale

Josse, Claire ; Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine

SCHROEDER, Hélène ; Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie

RORIVE, Andrée ; Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale

FRERES, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale

LAMBERT, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Génétique

KOOPMANSCH, Benjamin ; Centre Hospitalier Universitaire de Liège - CHU > Génétique

PONCIN, Aurélie ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine

BOURS, Vincent ; Centre Hospitalier Universitaire de Liège - CHU > Génétique

Language :

French

Title :

Cancer du sein : de la thérapie ciblée à la médecine personnalisée

Publication date :

2015

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

Issue :

5-6

Pages :

269-276

Peer reviewed :

Peer reviewed

Available on ORBi :

since 24 July 2015

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