Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study

[en] RATIONALE: Flesinoxan is a highly potent and selective 5-HT1A agonist. In a recent study, in normal volunteers, flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. OBJECTIVES: In order to better define the role of 5-HT receptor subtypes in response to flesinoxan, we assessed the influence of 5-HT1A and 5-HT2 antagonists on hormonal and temperature responses to flesinoxan. METHODS: Hormonal and temperature responses were studied in 6 volunteers with or without pretreatment with pindolol (30 mg p.o.), a 5-HT1A antagonist, or ritanserin (10 mg p.o.), a selective 5-HT2 antagonist, using a double-blind crossover design. RESULTS: Pindolol significantly antagonized ACTH, PRL, GH and temperature responses to flesinoxan and ritanserin exhibited similar activity on PRL and ACTH responses. CONCLUSIONS: These results show the role of 5-HT1A mechanisms in the PRL, ACTH, GH, and temperature responses to flesinoxan, and the role of 5-HT2 mechanisms in PRL and ACTH responses. Therefore, they confirm the interest of flesinoxan as a 5-HT neuroendocrine probe.

Disciplines :

Neurosciences & behavior
Neurology

Author, co-author :

Pitchot, William ; Centre Hospitalier Universitaire de Liège - CHU > Psychiatrie et psychologie médicale

Wauthy, Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département d'éducation et formation

Legros, Jean-Jacques ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Ansseau, Marc ; Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale

Language :

English

Title :

Hormonal and temperature responses to flesinoxan in normal volunteers: an antagonist study

Publication date :

March 2004

Journal title :

European Neuropsychopharmacology

ISSN :

0924-977X

eISSN :

1873-7862

Publisher :

Elsevier Science Bv, Amsterdam, Netherlands

Volume :

Issue :

Pages :

151-155

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 July 2015

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