Reference : Mesenchymal stem cells shed amphiregulin at the surface of lung carcinoma cells in a ...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/183930
Mesenchymal stem cells shed amphiregulin at the surface of lung carcinoma cells in a juxtacrine manner .
English
Carnet, Oriane* mailto [Université de Liège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Lecomte, Julie* [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Masset, Anne [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Primac, Irina mailto [Université de Liège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Durré, Tania mailto [Université de Liège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Maertens, Ludovic [Université of Liège - ULiège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Detry, Benoît [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Blacher, Silvia mailto [Université de Liège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Gilles, Christine mailto [Université de Liège > Département des sciences cliniques > LBTD/GIGA-cancer > >]
Péqueux, Christel mailto [Université de Liège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Paupert, Jenny [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > LBTD/GIGA-cancer > >]
Foidart, Jean-Michel mailto [Université de Liège > Département des sciences cliniques > Gynécologie - Obstétrique >]
Jerusalem, Guy mailto [Université de Liège > Département des sciences cliniques > Oncologie >]
Cataldo, Didier mailto [Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Noël, Agnès mailto [Université de Liège > Département des sciences cliniques > LBTD/GIGA-cancer > >]
* These authors have contributed equally to this work.
2015
Neoplasia
BC Decker
17
7
552-63
Yes (verified by ORBi)
International
1522-8002
1476-5586
Hamilton Ont
Canada
[en] Solid tumors comprise cancer cells and different supportive stromal cells, including mesenchymal stem cells (MSCs), which have recently been shown to enhance tumor growth and metastasis. We provide new mechanistic insights into how bone marrow (BM)-derived MSCs co-injected with Lewis lung carcinoma cells promote tumor growth and metastasis in mice. The proinvasive effect of BM-MSCs exerted on tumor cells relies on an unprecedented juxtacrine action of BM-MSC, leading to the trans-shedding of amphiregulin (AREG) from the tumor cell membrane by tumor necrosis factor-α-converting enzyme carried by the BM-MSC plasma membrane. The released soluble AREG activates cancer cells and promotes their invasiveness. This novel concept is supported by the exploitation of different 2D and 3D culture systems and by pharmacological approaches using a tumor necrosis factor-α-converting enzyme inhibitor and AREG-blocking antibodies. Altogether, we here assign a new function to BM-MSC in tumor progression and establish an uncovered link between AREG and BM-MSC.
http://hdl.handle.net/2268/183930
10.1016/j.neo.2015.07.002

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