Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

[en] Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy—tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a cell carrying an integrated provirus. After transcription, the viral genomic RNA undergoes reverse transcription and integration into the chromosomal DNA of a cell from the newly infected host. The virus then replicates by either one of two modes: (i) an infectious cycle by virus budding and infection of new targets and (ii) mitotic division of cells harboring an integrated provirus. HTLV-1 replication initiates a series of mechanisms in the host including antiviral immunity and checkpoint control of cell proliferation. HTLV-1 has elaborated strategies to counteract these defense mechanisms allowing continuous persistence in humans.

Disciplines :

Oncology

Author, co-author :

Carpentier, Alexandre ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Barez, Pierre-Yves ; Université de Liège - ULiège > Doct. sc. agro. & ingé. biol.

Hamaïdia, Malik ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Gazon, Hélène ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

De Brogniez, Alix ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Perike, Srikanth ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Gillet, Nicolas ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Willems, Luc ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biologie cell. et moléc.

Language :

English

Title :

Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence

Publication date :

07 July 2015

Journal title :

Viruses

eISSN :

1999-4915

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Special issue title :

Viral Replication Complexes: Structures, Functions, Applications and Inhibitors

Volume :

Pages :

3603-3624

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.mdpi.com/1999-4915/7/7/2793

Available on ORBi :

since 07 July 2015

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