Reference : Methof for the elution of 18F fluoride trapped on an anion-exchange phase in a form s...
Patent : Patent
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/183554
Methof for the elution of 18F fluoride trapped on an anion-exchange phase in a form suitable for efficient radiolabelling without any evaporation step
English
Aerts, Joël mailto [Université de Liège > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège > > Centre de recherches du cyclotron >]
Lignon, Steve [GE Healtcare > > > >]
Luxen, André mailto [Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
Morelle, Jean-Luc mailto []
Philippart, Gauthier mailto []
Voccia, Sam []
28-Aug-2008
2008-02-19
OEB
WO 2008/101305 A1
60/902.428 07447036.0
B
Belgique
Trasis SA, Université de Liège
C22B 3/42 G21G 1/10 A61K 51/00 B01D 15/36 C07B 59/00
?
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SV, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM,ZW.
ARIPO (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM,ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LI, LU, LV, MC, MT, NL NO, PL, PT, RO, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
[en] The invention relates to a method to ext. out of an aq. soln., conc. and​/or reformulate [18F] fluorides without any evapn. step, characterized in that the eluting soln. is a low water content, preferably <3​% water, org. soln. contg. at least: a first compd. (A) which is a tertiary alc.-​function bearing mol., a second compd. (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process. Said org. solvent is selected from acetonitrile (ACN)​, DMSO)​, dimethylacetamide, DMF, THF, di-​Et ether, dioxane, Et acetate, acetone, isobutyronitrile, benzonitrile, pyridine, di-​Et carbonate, sulfolane, hexamethylphosphotriamide (HMPA​/HMPT)​, and any mix of these solvents. Said nonpolar org. solvent is selected from pentane, hexane, heptane, octane, nonane, decane, and cyclohexane.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/183554

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