Patent (Patents)
Methof for the elution of 18F fluoride trapped on an anion-exchange phase in a form suitable for efficient radiolabelling without any evaporation step
Aerts, Joël; Lemaire, Christian; Lignon, Steve et al.
2008
 

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Abstract :
[en] The invention relates to a method to ext. out of an aq. soln., conc. and​/or reformulate [18F] fluorides without any evapn. step, characterized in that the eluting soln. is a low water content, preferably <3​% water, org. soln. contg. at least: a first compd. (A) which is a tertiary alc.-​function bearing mol., a second compd. (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process. Said org. solvent is selected from acetonitrile (ACN)​, DMSO)​, dimethylacetamide, DMF, THF, di-​Et ether, dioxane, Et acetate, acetone, isobutyronitrile, benzonitrile, pyridine, di-​Et carbonate, sulfolane, hexamethylphosphotriamide (HMPA​/HMPT)​, and any mix of these solvents. Said nonpolar org. solvent is selected from pentane, hexane, heptane, octane, nonane, decane, and cyclohexane.
Disciplines :
Chemistry
Inventor :
Aerts, Joël ;  Université de Liège > Centre de recherches du cyclotron
Lemaire, Christian ;  Université de Liège > Centre de recherches du cyclotron
Lignon, Steve;  GE Healtcare
Luxen, André ;  Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Morelle, Jean-Luc
Philippart, Gauthier
Voccia, Sam
Language :
English
Title (54) :
Methof for the elution of 18F fluoride trapped on an anion-exchange phase in a form suitable for efficient radiolabelling without any evaporation step
Publication date (43-45) :
28 August 2008
Filing date (22) :
19 February 2008
Patent/publication number (10-11) :
WO 2008/101305 A1
Patent status (13) :
B
Priority number (30) :
60/902.428 07447036.0
International classification (IPC) (51) :
C22B 3/42 G21G 1/10 A61K 51/00 B01D 15/36 C07B 59/00
European classification (ECLA) (52) :
?
Applicant (71) :
Trasis SA, Université de Liège
Publication organism (19) :
OEB
Available on ORBi :
since 02 July 2015

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