Reference : Differential effects of context on psychomotor sensitization to ethanol and cocaine
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Social & behavioral sciences, psychology : Animal psychology, ethology & psychobiology
http://hdl.handle.net/2268/183177
Differential effects of context on psychomotor sensitization to ethanol and cocaine
English
Didone, Vincent mailto [Université de Liège > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
Quoilin, Caroline [> >]
Dieupart, Julie [> >]
Tirelli, Ezio mailto [Université de Liège > Département de Psychologie : cognition et comportement > Neuroscience comportementale et psychopharmacologie expér. >]
Quertemont, Etienne mailto [Université de Liège > Département de Psychologie : cognition et comportement > Psychologie quantitative >]
2016
Behavioural Pharmacology
Lippincott Williams & Wilkins
27
2 & 3
173-181
Yes (verified by ORBi)
International
0955-8810
1473-5849
London
United Kingdom
[en] Cocaine ; Ethanol ; Locomotor activity ; Sensitization ; Novelty ; Mice
[en] Repeated drug injections lead to sensitization of their stimulant effects in mice, a phenomenon sometimes referred to as drug psychomotor sensitization. Previous studies showed that sensitization to cocaine is context dependent as its expression is reduced in an environment that was not paired with cocaine administration. In contrast, the effects of the test context on ethanol sensitization remain unclear. In the present study, female OF1 mice were repeatedly injected with 1.5 g/kg ethanol to test for both the effects of context novelty/familiarity and association on ethanol sensitization. A first group of mice was extensively pre-exposed to the test context before ethanol sensitization and ethanol injections were paired with the test context (familiar and paired group). A second group was not pre-exposed to the test context, but ethanol injections were paired with the test context (nonfamiliar and paired group). Finally, a third group of mice was not pre-exposed to the test context and ethanol was repeatedly injected in the home cage (unpaired group). Control groups were similarly exposed to the test context, but were injected with saline. In a second experiment, cocaine was used as a positive control. The same behavioral procedure was used, except that mice were injected with 10 mg/kg cocaine instead of ethanol. The results show a differential involvement of the test context in the sensitization to ethanol and cocaine. Cocaine sensitization is strongly context dependent and is not expressed in the unpaired group. In contrast, the expression of ethanol sensitization is independent of the context in which it was administered, but is strongly affected by the relative novelty/familiarity of the environment. Extensive pre-exposure to the test context prevented the expression of ethanol sensitization. One possible explanation is that expression of ethanol sensitization requires an arousing environment.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/183177
10.1097/FBP.0000000000000161

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