Towards a genotype-based approach for a patient-centered pharmacologic therapy of type 2 diabetes.

[en] The recent data reported by Tang and colleagues in Science Translational Medicine suggest that alpha-2 adrenoceptors (alpha2AAR) genetic heterogeneity may explain diverging results regarding the effects of alpha2AAR antagonists on insulin secretion and glucose control in patients with type 2 diabetes. They first confirmed that the risk variant for rs553668 (the A allele for a single-nucleotide polymorphism in ADRA2A) is likely to cause defective insulin secretion in human pancreatic islets. Second they showed that blocking alpha2AAR with yohimbine dose-dependently improves the reduced insulin secretion during an oral glucose tolerance test in patients with the risk variant. The successful translation of genomic information into clinical intervention in patients with type 2 diabetes provides proof of concept for the feasibility of individualized treatment based on genotype.

Disciplines :

Endocrinology, metabolism & nutrition
Pharmacy, pharmacology & toxicology

Author, co-author :

Scheen, André ; Université de Liège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques

Language :

English

Title :

Towards a genotype-based approach for a patient-centered pharmacologic therapy of type 2 diabetes.

Publication date :

2015

Journal title :

Annals of Translational Medicine

ISSN :

2305-5839

eISSN :

2305-5847

Publisher :

AME Publications, Hong Kong, China

Volume :

Issue :

Suppl 1

Pages :

S36

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 June 2015

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Bibliography

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