Article (Scientific journals)
Design of hybrid nanovehicles for remotely triggered drug release: an overview
Liu, Ji; Detrembleur, Christophe; Mornet, Stéphane et al.
2015In Journal of Materials Chemistry B, 3 (30), p. 6117-6147
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Keywords :
nanomedicine; biomaterial
Abstract :
[en] n the past few decades, various nanovehicles have been developed as drug delivery systems, in which inorganic and organic components are integrated within a nano-object. Upon the application of remote stimuli, e.g. alternating magnetic field, near infrared or ultrasound radiations, the release of guest molecules can be triggered in a quite controlled manner. Herein, we review different hybrid nanostructures which have already been reported for the remotely triggered release, such as those based on (1) host–guest conjugates, (2) core–corona nanoparticles, (3) polymer nanogels, (4) polymer micelles, (5) liposomes, (6) mesoporous silica particles and (7) hollow nanoparticles. Moreover, we also summarize six underlying mechanisms that govern such a kind of remotely triggered release behaviours: (1) enhanced diffusion and/or permeation, (2) thermo- or photo-labile bond cleavage, (3) fusion of phase-changed materials, (4) photo-induced isomerisation, (5) thermo-induced swelling/de-swelling of thermo-responsive polymers, and (6) destruction of the nanostructures. The ways in which different components are incorporated into an integrated hybrid nanostructure and how they contribute to the remotely triggered release behaviours are detailed.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry
Materials science & engineering
Author, co-author :
Liu, Ji;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Detrembleur, Christophe ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Mornet, Stéphane;  University of Bordeaux 1, France, Institut de Chimie de la Matière Consensée de Bordeaux, Chimie des nanomatériaux
Jérôme, Christine  ;  University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Duguet, Etienne;  University of Bordeaux 1, France, Institut de Chimie de la Matière Consensée de Bordeaux, Chimie des nanomatériaux
Language :
English
Title :
Design of hybrid nanovehicles for remotely triggered drug release: an overview
Publication date :
14 August 2015
Journal title :
Journal of Materials Chemistry B
ISSN :
2050-750X
eISSN :
2050-7518
Publisher :
Royal Society of Chemistry
Volume :
3
Issue :
30
Pages :
6117-6147
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
The International Doctoral School IDS-Funmat
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