[en] To examine the relationship of insulin and glucose, broiler embryos were subjected to acute or prolonged hypoglycemia during the late embryonic phase by, respectively, injecting once (at embryonic day [ED] 16 or 17) or on 3 consecutive days (ED 16, 17, and 18) with tolbutamide (80?g/g embryo weight), a substance that stimulates insulin secretion from the pancreas. After 1 tolbutamide injection, a prolonged (32h) decrease of plasma glucose and a profound acute increase in plasma insulin were observed. The 3 consecutive tolbutamide injections induced hypoglycemia for 4 days (from ED 16 to ED 19). The postnatal performance after 3 consecutive tolbutamide injections in broiler embryos was also investigated. Body weight was lower in tolbutamide-treated chickens from hatch to 42d compared with sham (. P = 0.001) and control (. P < 0.001) chickens. Feed intake was lower in the tolbutamide group from hatch to 42d as compared with sham (. P = 0.007) and control (. P = 0.017) animals. In addition, at 42d, plasma glucose concentrations, after an insulin injection challenge (50?g/kg body weight), were higher in tolbutamide-treated chickens compared with the sham and the control group as were their basal glucose levels (. P value of group effect <0.001). In conclusion, tolbutamide treatment during the late embryonic development in broilers resulted in prolonged hypoglycemia in this period and negatively influenced the posthatch performance. 2015 Elsevier Inc.
Disciplines :
Animal production & animal husbandry
Author, co-author :
Franssens, L.; Laboratory of Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, Belgium
Lesuisse, J.; Laboratory of Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, Belgium
Wang, Y.; Laboratory of Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, Belgium
De Ketelaere, B.; Division of MeBioS, Department of Biosystems, KU Leuven, Leuven, Belgium
Willems, E.; Laboratory of Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, Belgium
Koppenol, A.; Laboratory of Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, Belgium, Animal Sciences Unit, Instituut voor Landbouw- en Visserijonderzoek, Melle, Belgium
Guo, X.; College of Animal Science and Technology, Jiangxi Agricultural University, Jiangxi, China
Buyse, J.; Laboratory of Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, Belgium
Decuypere, E.; Laboratory of Livestock Physiology, Department of Biosystems, KU Leuven, Leuven, Belgium
Everaert, Nadia ; Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Zootechnie
Language :
English
Title :
Prenatal tolbutamide treatment alters plasma glucose and insulin concentrations and negatively affects the postnatal performance of chickens
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