Preparation and characterizations of EGDE crosslinked chitosan electrospun membranes

[en] Composite Crosslinked nanofibrous membranes of chitosan, ethylene glycol diglycidyl ether (EGDE) and polyethy- 10 lene oxide was successfully prepared with bead free morphology via electrospinning technique followed by heat mediated 11 chemical crosslinking. Architectural stability of nanofiber mat in aqueous medium was achieved by chemical crosslinking of 12 only 1% EGDE, and tensile strength tests revealed that increasing EGDE content has considerably enhance the elastic modu- 13 lus of nanofibers. The structure, morphology and mechanical properties of nanofibers were characterized by Attenuated Total 14 Reflection-Fourier Transform Infrared spectroscopy (ATR–FTIR), scanning electron microscopy (SEM) and Instron machine, 15 respectively. Skin fibroblasts and endothelial cells showedgood attachment, proliferation and viability on crosslinked electrospun 16 membranes. The results indicate a good biocompatibility and non-toxic nature of the resulted membrane.

Research Center/Unit :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Aqil, Abdelhafid ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Tchemtchoua Tateu, Victor ; University of Liège (ULg), GIGA Research Center, Laboratory of Connective Tissues

Colige, Alain ; University of Liège (ULg), GIGA Research Center, Laboratory of Connective Tissues

Atanasova, Ganka; University of Namur (FUNDP), Laboratory of Cells and Tissues

Poumay, Yves; University of Namur (FUNDP), Laboratory of Cells and Tissues

Jérôme, Christine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Preparation and characterizations of EGDE crosslinked chitosan electrospun membranes

Publication date :

2015

Journal title :

Clinical Hemorheology and Microcirculation

ISSN :

1386-0291

Publisher :

IOS Press, Amsterdam, Netherlands

Volume :

Issue :

Pages :

39-50

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

The Walloon Region (Directorate General for Technologies, Research, and Energy

Available on ORBi :

since 04 June 2015

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