Glioblastoma stem cells: new insights in therapeutic strategies

Goffart, Nicolas; Dedobbeleer, Matthias; Rogister, Bernard

doi:10.2217/fnl.14.56

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Glioblastoma stem cells: new insights in therapeutic strategies

Goffart, Nicolas; Dedobbeleer, Matthias; Rogister, Bernard

2014 • In Future Neurology, 9 (6), p. 639-653

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10.2217/fnl.14.56

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Keywords :

chemotherapy; Glioblastoma; Glioblastoma stem cells; Immunotherapy; Radiotherapy; Surgery

Abstract :

[en] Despite notable achievements in glioblastoma diagnosis and treatment, the prognosis of glioblastoma patients remains poor and reflects the failure of current therapeutic modalities. In this context, innovative therapeutic strategies have recently been developed to specifically target glioblastoma stem cells, a subpopulation of tumor cells involved in experimental tumorigenesis and known to be critical for tumor recurrence and therapeutic resistance. The current review summarizes the different trails which make glioblastoma stem cells resistant to treatments, mainly focusing on radio-, chemo- and immunotherapy. This broad overview might actually help to set up new bases for glioblastoma therapy in order to better fight tumor relapses and to improve the patients’ prognosis.

Disciplines :

Oncology

Author, co-author :

Goffart, Nicolas ; Université de Liège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Dedobbeleer, Matthias ; Université de Liège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Rogister, Bernard ; Université de Liège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine

Language :

English

Title :

Glioblastoma stem cells: new insights in therapeutic strategies

Publication date :

November 2014

Journal title :

Future Neurology

ISSN :

1479-6708

eISSN :

1748-6971

Publisher :

Future Medicine Ltd, London, United Kingdom

Volume :

Issue :

Pages :

639-653

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 May 2015

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