Drug loading of polymer implants by supercritical CO2 assisted impregnation: a review

[en] Drug loaded implants also called drug-eluting implants have proven their benefits over simple implants. Among the developed manufacturing processes, the supercritical CO2 (scCO2) assisted impregnation has attracted growing attention to load Active Pharmaceutical Ingredients into polymer implants since it enables to recover a final implant free of any solvent residue and to operate under mild temperature which is suitable for processing with thermosensitive drugs. This paper is a review of the state-of-the-art and the application of the scCO2 assisted impregnation process to prepare drug-eluting implants. It introduces the process and presents its advantages for biomedical applications. The influences of the characteristics of the implied binary systems and of the experimental conditions on the drug loading are described. Then, the various current applications of this process for manufacturing drug-eluting implants are reviewed. Finally, the new emerging variations of this process are described.

Research center :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Materials science & engineering
Chemistry

Author, co-author :

Champeau, Mathilde; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Thomassin, Jean-Michel ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Tassaing, Thierry; University of Bordeaux, Institute of Molecular Sciences, France

Jérôme, Christine ; University of Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Drug loading of polymer implants by supercritical CO2 assisted impregnation: a review

Publication date :

10 July 2015

Journal title :

Journal of Controlled Release

ISSN :

0168-3659

eISSN :

1873-4995

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

209

Pages :

248-259

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

BELSPO - Politique scientifique fédérale [BE]
The International Doctoral School IDS-Funmat
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Conseil Général d'Aquitaine [FR]

Available on ORBi :

since 12 May 2015

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Scopus citations^®

197

Scopus citations^®
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189

OpenCitations

166

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