Développement de méthodes séparatives pour détecter la contrefaçon de molécules biosynthétiques comme l'insuline et les GHRP

Counterfeiting is a widespread problem in the world. The medicines, like insulin or GHRP, need a strict quality control. Capillary electrophoresis and liquid chromatography methods were developed to analyze these peptides. The human insulin and its different analogues (lispro, aspart, glulisin, glargin and detemir) were separated by MEKC within 15 minutes. The GHRP-2 and -6 were separated by HPLC also in 15 minutes. Several samples of GHRP-6 were analyzed and non-compliances were reported. These analytical approaches seem to be promising to fight against the counterfeiting of such medicines.