Simultaneous determination of insulin and its analogues in pharmaceutical formulations by micellar electrokinetic chromatography

Lamalle, Caroline; Servais, Anne-Catherine; RADERMECKER, Régis; Crommen, Jacques; Fillet, Marianne

doi:10.1016/j.jpba.2014.12.038

Article (Scientific journals)

Simultaneous determination of insulin and its analogues in pharmaceutical formulations by micellar electrokinetic chromatography

Lamalle, Caroline; Servais, Anne-Catherine; RADERMECKER, Régis et al.

2015 • In Journal of Pharmaceutical and Biomedical Analysis

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/180834

DOI
10.1016/j.jpba.2014.12.038

PubMed
25599910

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Keywords :

counterfeit medicines; insulin; micellar electrokinetic chromatography; quality control; stability

Abstract :

[en] A simple and efficient MEKC method was developed to simultaneously determine human insulin, its five analogues, the main degradation products and the excipients usually present in injection formulations. A very fast method with a total analysis time of 3 min was then successfully validated for the analysis of human insulin and the quality control of different commercial formulations was carried out.

Research center :

Centre Interfacultaire de Recherche du Médicament - CIRM

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Lamalle, Caroline ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Servais, Anne-Catherine ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

RADERMECKER, Régis ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques

Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Language :

English

Title :

Simultaneous determination of insulin and its analogues in pharmaceutical formulations by micellar electrokinetic chromatography

Publication date :

2015

Journal title :

Journal of Pharmaceutical and Biomedical Analysis

ISSN :

0731-7085

eISSN :

1873-264X

Publisher :

Elsevier Science, Oxford, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Available on ORBi :

since 24 April 2015

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Bibliography

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