Article (Scientific journals)
Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.
Weets, I.; Truyen, I.; Verschraegen, I. et al.
2006In Diabetologia, 49 (6), p. 1158-62
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Keywords :
Adolescent; Adult; Age of Onset; Autoantibodies/blood; Belgium/epidemiology; C-Peptide/blood; Child; Child, Preschool; Diabetes Mellitus, Type 1/blood/diagnosis/epidemiology/immunology; Female; HLA-DQ Antigens/blood; Humans; Infant; Male; Registries; Sex Characteristics
Abstract :
[en] AIMS/HYPOTHESIS: The incidence of type 1 diabetes varies according to age, sex and season of diagnosis. We investigated whether these and other clinical, biological and anthropometric parameters were correlated with residual beta cell function in newly diagnosed patients, since it is possible that the nature of external and/or genetic disease accelerators may be (partly) reflected in the inaugural disease presentation. MATERIALS AND METHODS: The correlates of random C-peptide levels sampled shortly after diagnosis (median [interquartile range]: 3 [0-14] days) were studied by multivariate analysis in 1,883 islet-antibody-positive diabetic patients aged <40 years who were diagnosed between 1989 and 2000. RESULTS: Higher C-peptide levels (above percentile 50 of patients) were associated with older age at diagnosis, female sex, diagnosis in the high-incidence season (October to March), less-decreased BMI (expressed as a standard deviation score), lower insulin requirements after stabilisation, lower prevalence of ketonuria and a less-increased glycaemia at diagnosis (all p < 0.001). C-peptide levels were not correlated with calendar year at diagnosis, duration of symptoms prior to diagnosis, HLA-DQ2/DQ8 genotype or islet antibody status. CONCLUSIONS/INTERPRETATION: Sex- and season-dependent differences in residual functional beta cell mass and/or insulin resistance have been identified at diagnosis of type 1 diabetes. They may reflect differences in disease-precipitating external or lifestyle factors and should be further investigated longitudinally in prediabetes to further identify putative aetiological factors, which may provide targets for prevention.
Disciplines :
Pediatrics
Endocrinology, metabolism & nutrition
Author, co-author :
Weets, I.
Truyen, I.
Verschraegen, I.
Van der Auwera, B.
De Schepper, J.
Dorchy, H.
LEBRETHON, Marie-Christine ;  Centre Hospitalier Universitaire de Liège - CHU > Pédiatrie
Van Gaal, L.
Van Rooy, P.
Pipeleers, D. G.
Gorus, F. K.
Language :
English
Title :
Sex- and season-dependent differences in C-peptide levels at diagnosis of immune-mediated type 1 diabetes.
Publication date :
2006
Journal title :
Diabetologia
ISSN :
0012-186X
eISSN :
1432-0428
Publisher :
Springer, Germany
Volume :
49
Issue :
6
Pages :
1158-62
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 April 2015

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