Article (Scientific journals)
Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis.
Conteduca, Giuseppina
2011In Clinical Immunology, 139 (3), p. 249-57
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Keywords :
TH17; Treg; systemic sclerosis.
Abstract :
[en] Aim of the study has been to understand the relationship between TH17 and Treg cell subsets in patients affected with systemic sclerosis (SSc). Phenotypes and functions of Th17 and Treg cell subsets were analyzed in a series of 36 SSc patients. Th17 cell concentration in the peripheral blood was found to be increased in SSc patients with respect to healthy controls independently from type or stage of disease. After PBMC stimulation with a polyclonal stimulus or Candida albicans antigens the frequency of Th17 T cell clones was significantly higher in SSc patients with respect to controls suggesting the skewing of immune response in SSc patients toward Th17 cell generation/expansion. Concerning the Treg compartment, both CD4+CD25+ and CD8+CD28- Treg subsets showed quantitative and qualitative alteration in the peripheral blood of SSc patients. Collectively, these data highlight the existence of an imbalanced ratio between Th17 and Treg cell subsets in SSc patients.
Research center :
Centre of Excelence for Biomedical Research
Disciplines :
Hematology
Author, co-author :
Conteduca, Giuseppina ;  Università degli studi di Genova, Italy > CEBR > Immunology > 2011
Language :
English
Title :
Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis.
Publication date :
June 2011
Journal title :
Clinical Immunology
ISSN :
1521-6616
eISSN :
1521-7035
Publisher :
Academic Press, San Diego, United States - California
Volume :
139
Issue :
3
Pages :
249-57
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Th17 and Treg in systemic sclerosis.
Funders :
Carige, San Paolo, Sclero, Associazione Italiana Sclerodermia
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