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Core-shell AgSiO2-Protoporphyrin IX nanoparticle: Effect of the Ag core on reactive oxygen species generation
Lismont, Marjorie; Pàez Martinez, Carlos; Dreesen, Laurent
2015In SPIE proceeding - Colloidal Nanoparticles for Biomedical Applications X
Peer reviewed
 

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Keywords :
Ag@SiO2 core-shell NPs; Protoporphyrin IX; Reactive oxygen species
Abstract :
[en] Photodynamic therapy (PDT) for cancer is based on the use of a light sensitive molecule to produce, under specific irradiation, toxic reactive oxygen species (ROS). A way to improve the therapy efficiency is to increase the amount of produced ROS near cancer cells. This aim can be achieved by using a metal enhanced process arising when an optically active molecule is located near a metallic nanoparticle (NP). Here, the coupling effect between silver (Ag) NPs and protoporphyrin IX (PpIX) molecules, a clinically approved photosensitizer, is studied compared first, to PpIX fluorescence yield and second, to ROS production efficiency. By applying a modified Stöber process, PpIX was encapsulated into a silica (SiO2) shell, surrounding a 60 nm sized Ag core. We showed that, compared to SiO2-PpIX NPs, Ag coated SiO2-PpIX NPs dramatically decreased PpIX fluorescence together with singlet oxygen production efficiency. However, after incubation time in the dark, the amount of superoxide anions generated by the Ag doped sample was higher than the control sample one.
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Lismont, Marjorie ;  Université de Liège - ULiège > Département de physique > Biophotonique
Pàez Martinez, Carlos ;  Université de Liège - ULiège > Département de chimie appliquée > Génie chimique - Nanomatériaux et interfaces
Dreesen, Laurent ;  Université de Liège - ULiège > Département de physique > Biophotonique
Language :
English
Title :
Core-shell AgSiO2-Protoporphyrin IX nanoparticle: Effect of the Ag core on reactive oxygen species generation
Publication date :
February 2015
Event name :
SPIE Photonics West 2015
Event place :
San Francisco, United States
Event date :
du 7 février 2015 au 12 février 2015
Audience :
International
Main work title :
SPIE proceeding - Colloidal Nanoparticles for Biomedical Applications X
Peer reviewed :
Peer reviewed
Available on ORBi :
since 19 January 2015

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