Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction.

Morelle, J.; Labriola, L.; Lambert, Michel; Cosyns, J.-P.; JOURET, François; Jadoul, M.

doi:10.5414/CNP71567

Article (Scientific journals)

Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction.

Morelle, J.; Labriola, L.; Lambert, Michel et al.

2009 • In Clinical Nephrology, 71 (5), p. 567-70

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/176641

DOI
10.5414/CNP71567

PubMed
19473619

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Keywords :

Acute Kidney Injury/chemically induced/pathology; Adenine/adverse effects/analogs & derivatives/therapeutic use; Anti-HIV Agents/adverse effects/therapeutic use; Anti-Inflammatory Agents, Non-Steroidal/adverse effects/therapeutic use; Biopsy; Diagnosis, Differential; Diclofenac/adverse effects/therapeutic use; Drug Synergism; Drug Therapy, Combination; Fanconi Syndrome/chemically induced/pathology; Female; HIV Antibodies/immunology; HIV Seropositivity/drug therapy/virology; HIV-1/immunology; Humans; Kidney Tubules, Proximal/drug effects/pathology; Middle Aged; Phosphonic Acids/adverse effects/therapeutic use

Abstract :

[en] We describe an HIV1-positive patient under long-term tenofovir treatment who developed a severe, biopsy-proven, acute tubular necrosis with proximal tubule (PT) dysfunction, precipitated by the very recent start of diclofenac, a nonsteroidal antiinflammatory drug (NSAID). Recent studies show that NSAIDs not only alter glomerular filtration but also multidrug resistance protein (MRP) 4-mediated PT secretion of several substrates. Since the patient tolerated tenofovir well for several years prior to diclofenac use, our observation suggests that diclofenac interfered with tenofovir clearance, thereby favoring its nephrotoxicity. NSAIDs should be avoided in patients under tenofovir.

Disciplines :

Urology & nephrology

Author, co-author :

Morelle, J.

Labriola, L.

Lambert, Michel

Cosyns, J.-P.

JOURET, François ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

Jadoul, M.

Language :

English

Title :

Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction.

Publication date :

2009

Journal title :

Clinical Nephrology

ISSN :

0301-0430

Publisher :

Dustri-Verlag Dr. Karl Feistle, Germany

Volume :

Issue :

Pages :

567-70

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 January 2015

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