Article (Scientific journals)
Comparison between Alprazolam and Hydroxyzine for Oral Premedication
Franssen, Colette; Hans, Pol; Brichant, Jean-François et al.
1993In Canadian Journal of Anaesthesia, 40 (1), p. 13-7
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Abstract :
[en] The safety and efficacy of alprazolam and hydroxyzine administered orally as surgical premedicants were compared in a double-blind controlled study. Sixty-five patients were given either alprazolam 1 mg or hydroxyzine 75 mg, one to two hours before surgery. Anxiety was assessed by both the patient and the anaesthetist, the patient using a visual analogue scale, the anaesthetist employing both analogue and ordinal ratings. Sedation was assessed by the anaesthetist only, using the same two methods. Amnesia was appraised with a simple memory test. Safety was assessed by recording adverse effects and measuring haemodynamic variables. Premedication with alprazolam produced a modest reduction in anxiety (28%) (P < 0.01) while hydroxyzine had no detectable effect. The comparison of the sedation level and of the memory test revealed no difference between the two premedicants. Minor side effects were only observed in the hydroxyzine group. Changes in blood pressure were more pronounced in the hydroxyzine group. This study shows that alprazolam and hydroxyzine are safe and efficient oral premedicants. However, alprazolam is preferable to hydroxyzine in terms of anxiolytic and adverse effects.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Franssen, Colette ;  Université de Liège - ULiège > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires
Hans, Pol ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Brichant, Jean-François ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Noirot, D.
Lamy, Maurice ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Language :
English
Title :
Comparison between Alprazolam and Hydroxyzine for Oral Premedication
Publication date :
January 1993
Journal title :
Canadian Journal of Anaesthesia
ISSN :
0832-610X
eISSN :
1496-8975
Publisher :
Canadian Anesthesiolgists' Society/Société Canadienne des Anesthesistes, Canada
Volume :
40
Issue :
1
Pages :
13-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 December 2008

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