Article (Scientific journals)
Le medicament du mois. Ulipristal acetate: une contraception d'urgence etendue a 5 jours par progesterone receptor modulator (Ellaone).
Gaspard, Ulysse; Kridelka, Frédéric
2010In Revue Médicale de Liège, 65 (12), p. 700-5
Peer reviewed
 

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Keywords :
Contraception, Postcoital; Contraceptives, Postcoital/pharmacology; Female; Humans; Norpregnadienes/pharmacology
Abstract :
[en] Emergency contraception is a second chance for prevention of pregnancy after unprotected intercourse. Hormonal emergency contraception with levonorgestrel 1.5 mg, only provides an effective contraception from 0 to 72 hours after intercourse with decreasing effectiveness as time elapses. It was accordingly mandatory to develop an alternative approach with a stable contraceptive efficacy and good tolerance for 5 days, knowing additionally that the estimated lifespan of sperm in the female genital tract is about 5 days. In comparative studies bearing on more than 3000 young women, the progesterone receptor modulator (PRM) ulipristal acetate, a progesterone antagonist (taken in a single dose of 30 mg), or levonorgestrel (1.5 mg) were administered. Results indicated that the PRM was as effective as levonorgestrel, or even more, kept a stable efficacy for 120 hours after an unprotected intercourse, and was well tolerated. This establishes ulipristal acetate as the new standard for hormonal emergency contraception.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Gaspard, Ulysse ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Kridelka, Frédéric ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie et obstétrique
Language :
French
Title :
Le medicament du mois. Ulipristal acetate: une contraception d'urgence etendue a 5 jours par progesterone receptor modulator (Ellaone).
Alternative titles :
[en] Ulipristal acetate: an emergency contraception extended to 5 days using a progesterone receptor modulator (Ellaone)
Publication date :
2010
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Volume :
65
Issue :
12
Pages :
700-5
Peer reviewed :
Peer reviewed
Available on ORBi :
since 26 December 2014

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