Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties

Khadem, A.; Soler, L.; Everaert, Nadia; Niewold, T. A.

doi:10.1017/S0007114514001871

Article (Scientific journals)

Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties

Khadem, A.; Soler, L.; Everaert, Nadia et al.

2014 • In British Journal of Nutrition

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/173857

DOI
10.1017/S0007114514001871

PubMed
25181450

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Keywords :

Anti-inflammatory properties; Antimicrobial growth promoters; Oxytetracycline; Sanguinarine

Abstract :

[en] The non-antibiotic anti-inflammatory theory of antimicrobial growth promoters (AGP) predicts that alternatives can be selected by simple in vitro tests. In vitro, the known AGP oxytetracycline (OTC) and a Macleaya cordata extract (MCE) had an anti-inflammatory effect with a half-maximal inhibitory concentration of 88 and 132 mg/l, respectively. In vivo, chickens received three different concentrations of MCE in drinking-water, OTC in feed and a control. Body weight (BW), feed intake (FI) and gain:feed (G:F) ratio were determined on days 14, 21 and 35. On day 35, body composition was determined. Plasma α1-acid glycoprotein (α1-AG) concentration was measured on days 21 and 35, and the expression of several jejunal inflammatory genes was determined on day 35. OTC-fed chickens showed a significantly higher BW, FI and G:F ratio compared with the control group at all time points. MCE had a significant linear effect on BW on days 21 and 35, and the G:F ratio was improved only over the whole period, whereas FI was not different. Only MCE but not OTC decreased the percentage of abdominal fat. Plasma α1-AG concentration increased from day 21 to 35, with the values being lower in the treatment groups. Both OTC and MCE significantly reduced the jejunal mucosal expression of inducible NO synthase. For most parameters measured, there was a clear linear dose-response to treatment with MCE. In conclusion, the results are consistent with the anti-inflammatory theory of growth promotion in production animals. Copyright © The Authors 2014.

Disciplines :

Animal production & animal husbandry

Author, co-author :

Khadem, A.; Division of Livestock-Nutrition-Quality, Department of Biosystems, Faculty of Bioscience Engineering, KU Leuven, Kasteelpark Arenberg 30, B-3001 Heverlee, Belgium

Soler, L.; Division of Livestock-Nutrition-Quality, Department of Biosystems, Faculty of Bioscience Engineering, KU Leuven, Kasteelpark Arenberg 30, B-3001 Heverlee, Belgium

Everaert, Nadia ; KU Leuven > Department of Biosystems

Niewold, T. A.; Division of Livestock-Nutrition-Quality, Department of Biosystems, Faculty of Bioscience Engineering, KU Leuven, Kasteelpark Arenberg 30, B-3001 Heverlee, Belgium

Title :

Growth promotion in broilers by both oxytetracycline and Macleaya cordata extract is based on their anti-inflammatory properties

Publication date :

2014

Journal title :

British Journal of Nutrition

ISSN :

0007-1145

eISSN :

1475-2662

Publisher :

Cambridge University Press, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 13 November 2014

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