Image-guided failure assessment of human trabecular bone - Inverse finite element modelling for characterization of elastic properties

Local interpretation of micro finite element (mu FE) simulations has become important in different fields of bone biomechanics. Although on an apparent level mu FE has successfully been validated against experiments, local validations are sparse and limited by imaging resolution. At the tissue level heterogeneity of Young's modulus has been reported. Although non-uniform material distribution have been shown to only have a minor influence on the apparent material properties, its impact on local material behaviour is largely unknown. By combining image-guided failure assessment (IGFA) using synchrotron-based-micro-computed tomography, strain mapping and inverse mu FE modelling, we present an experimental and computational framework which will allow studying local effects of intratrabecular heterogeneity of the Young's modulus.