Article (Scientific journals)
Procalcitonin for antibiotic treatment in intensive care unit patients.
LAYIOS, Nathalie; LAMBERMONT, Bernard
2013In Current Infectious Disease Reports, 15 (5), p. 394-9
Peer reviewed
 

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Abstract :
[en] Procalcitonin (PCT), a 116-aminoacids prohormone, has been substantially studied over the last 2 decades in the field of sepsis. Disappointingly low sensitivity values led to the abandonment of the concept of it as a diagnostic tool and then to its being considered more as a prognostic marker with a good correlation with severe infection. Later on, growing concerns about multidrug-resistant bacteria in the ICU environment and about the cost and side effects of antibiotics suggested that PCT might prove to be a valuable asset in stewardship programs. Numerous but hardly comparable randomized controlled trials assessing either initiation or deescalation in ICU patients have been published. Stewardship encompassing PCT should focus on the latter, because of the high negative predictive value of this biomarker. However, there still would be safety concerns if a systematic implementation of PCT were to be considered in daily stewardship programs in the ICU, especially in extra-thoracic sepsis.
Disciplines :
Anesthesia & intensive care
General & internal medicine
Author, co-author :
LAYIOS, Nathalie  ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
LAMBERMONT, Bernard  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine
Language :
English
Title :
Procalcitonin for antibiotic treatment in intensive care unit patients.
Publication date :
2013
Journal title :
Current Infectious Disease Reports
ISSN :
1523-3847
eISSN :
1534-3146
Publisher :
Current Science, United States
Volume :
15
Issue :
5
Pages :
394-9
Peer reviewed :
Peer reviewed
Available on ORBi :
since 07 October 2014

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