Article (Scientific journals)
Sputum cytokines levels in patients undergoing hematopoietic SCT (HSCT) and comparison with healthy subjects and COPD: a pilot study
MOERMANS, Catherine; BONNET, Christophe; WILLEMS, Evelyne et al.
2014In Bone Marrow Transplantation, 49 (11), p. 1382-1388
Peer Reviewed verified by ORBi
 

Files


Full Text
Sputum cytokine levels in patients undergoing..._14_Moermans_Bone_Marow_Transplantation.pdf
Publisher postprint (462.91 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
HSCT; sputum; neutrophil; cytokines; IL-6; IL-8
Abstract :
[en] Patients undergoing hematopoietic stem cell transplantation (HSCT) display an airway neutrophilic inflammation before the transplantation that persists over the years. In this study, we have investigated the cytokine profile over a period of one year in sputum supernatant of patients who underwent HSCT. We have measured sputum supernatant levels of TNF-α, TGF-β1, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17, and IFN-γ in 49 HSCT patients and compared the results with those found in 40 COPD and 54 healthy subjects matched for age. Compared to healthy subjects, before the transplantation, HSCT patients exhibited raised levels of IL-6 (p<0.001) and IL-8 (p<0.05) while the other cytokines were generally poorly detectable. This picture was rather similar to what is seen in COPD even if cytokine levels were much greater in the latter with IL-8 being significantly greater in COPD than in HSCT patients (p<0.0001). In the 1 year following the transplantation, sputum IL-6 and IL-8 did not differ any longer compared to healthy subjects. Overall in HSCT patients, sputum IL-8 and IL-6 correlated with sputum neutrophil counts (r=0.4, p<0.0001; r=0.42, p<0.0001, respectively). In conclusion, sputum IL-6 and IL-8 may play a role in neutrophilic airway inflammation seen in patients undergoing HSCT.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
MOERMANS, Catherine  ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
BONNET, Christophe ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
WILLEMS, Evelyne ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Baron, Frédéric  ;  Université de Liège - ULiège > GIGA-R : Hématologie
NGUYEN DANG, Delphine ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
HENKET, Monique ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Sele, Jocelyne
CORHAY, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Language :
English
Title :
Sputum cytokines levels in patients undergoing hematopoietic SCT (HSCT) and comparison with healthy subjects and COPD: a pilot study
Publication date :
November 2014
Journal title :
Bone Marrow Transplantation
ISSN :
0268-3369
eISSN :
1476-5365
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
49
Issue :
11
Pages :
1382-1388
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 October 2014

Statistics


Number of views
93 (29 by ULiège)
Number of downloads
12 (12 by ULiège)

Scopus citations®
 
8
Scopus citations®
without self-citations
5
OpenCitations
 
5

Bibliography


Similar publications



Contact ORBi