[en] Natriuretic peptides are cardiac biomarkers, routinely used for diagnosis, prognosis, and guidance for treatment in human and small animal cardiology. However, their diagnostic and prognostic value in horses has received little study. The aim of this study was to investigate the plasma atrial natriuretic concentration (ANPPl) in a large group of horses with various degrees of valvular regurgitation (VR) and congestive heart failure (CHF).
Clinical examination and two-dimensional, time-motion mode and Doppler echocardiography were performed on 91 horses admitted to the Equine Teaching Hospital of Liege University, with either no, mild, moderate or severe VR and presenting various stages of CHF. ANPPl was measured using a commercially available human RIA test. Mean values of body weight, age, ANPPl and echocardiographic parameters were compared between horses with no, mild, moderate and severe VR and between horses in different CHF stages. Correlation and linear regression of ANPPl with each echocardiographic parameter and with the percentage of dilation of each of cardiac chambers were assessed.
Horses with severe or moderate VR had significantly higher ANPPl than horses with mild or no VR. ANPPl was significantly higher in horses presenting CHF than in horses without CHF. ANPPl was significantly correlated with the left atrial diameter and its percentage of dilation. These results suggest a diagnostic value of ANPPl in horses with VR, especially with tricuspid or mitral insufficiency with dilation of the atria.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Leroux, Aurélia ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
Cerri, Simona ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
Houben, Rosa ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des équidés
Sandersen, Charlotte ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires
Moula, Nassim ; Université de Liège - ULiège > Scientifiques attachés au Doyen (F MV)
scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.
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