Article (Scientific journals)
Estimated daily intake and cumulative risk assessment of phthalate diesters in a Belgian general population
Dewalque, Lucas; Charlier, Corinne; PIRARD, Catherine
2014 • In Toxicology Letters, 231 (2), p. 161-168
Peer Reviewed verified by ORBi
 

Files


Full Text
Lucas_Toxicol Let 2014.pdf
Publisher postprint (570.17 kB)
Request a copy

http://www.sciencedirect.com


All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Phthalate; Daily intake; Urine; Belgium; Hazard index
Abstract :
[en] The daily intakes (DI) were estimated in a Belgian general population for 5 phthalates, namely diethyl phthalate (DEP), di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), butylbenzyl phthalate (BBzP) and di-2-ethylhexyl phthalate (DEHP), based on the urinary measurements of their corresponding metabolites. DI values ranged between
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Dewalque, Lucas ;  Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
Charlier, Corinne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
PIRARD, Catherine  ;  Centre Hospitalier Universitaire de Liège - CHU > Toxicologie clinique
Language :
English
Title :
Estimated daily intake and cumulative risk assessment of phthalate diesters in a Belgian general population
Publication date :
2014
Journal title :
Toxicology Letters
ISSN :
0378-4274
eISSN :
1879-3169
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
231
Issue :
2
Pages :
161-168
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 September 2014

Statistics


Number of views
267 (9 by ULiège)
Number of downloads
3 (3 by ULiège)

Scopus citations®
 
114
Scopus citations®
without self-citations
113
OpenAlex citations
 
121

Bibliography


  • Anderson W.A., Castle L., Scotter M.J., Massey R.C., Springall C. A biomarker approach to measuring human dietary exposure to certain phthalate diesters. Food Addit. Contam. 2001, 18:1068-1074.
  • Anderson W.A., Castle L., Hird S., Jeffery J., Scotter M.J. A twenty-volunteer study using deuterium labelling to determine the kinetics and fractional excretion of primary and secondary urinary metabolites of di-2-ethylhexylphthalate and di-iso-nonylphthalate. Food Chem. Toxicol. 2011, 49:2022-2029.
  • Aylward L.L., Hays S.M., Gagné M., Krishnan K. Derivation of biomonitoring equivalents for di(2-ethylhexyl)phthalate (CAS no. 117-81-7). Regul. Toxicol. Pharmacol. 2009, 55:249-258.
  • Aylward L.L., Kirman C.R., Adgate J.L., McKenzie L.M., Hays S.M. Interpreting variability in population biomonitoring data: role of elimination kinetics. J. Expo. Sci. Environ Epidemiol. 2012, 22:398-408.
  • Bekö G., Weschler C.J., Langer S., Callesen M., Toftum J., Clausen G. Children's phthalate intakes and resultant cumulative exposures estimated from urine compared with estimates from dust ingestion, inhalation and dermal absorption in their homes and daycare centers. PLoS One 2013, 8:e62442.
  • Benson R. Hazard to the developing male reproductive system from cumulative exposure to phthalate esters-dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate. Regul. Toxicol. Pharmacol. 2009, 53:90-101.
  • Borch J., Axelstad M., Vinggaard A.M., Dalgaard M. Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis. Toxicol. Lett. 2006, 163:183-190.
  • Calafat A.M., McKee R.H. Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study. Environ. Health Perspect. 2006, 114:1783-1789.
  • Chen L., Zhao Y., Li L., Chen B., Zhang Y. Exposure assessment of phthalates in non-occupational populations in China. Sci. Total Environ. 2012, 427-428:60-69.
  • Christensen K.L., Lorber M., Koch H.M., Kolossa-Gehring M., Morgan M.K. Population variability of phthalate metabolites and bisphenol A concentrations in spot urine samples versus 24- or 48-h collections. J. Expo. Sci. Environ. Epidemiol. 2012, 22:632-640.
  • David R.M. Exposure to phthalate esters. Environ. Health Perspect. 2000, 108:A440.
  • Dewalque L., Pirard C., Dubois N., Charlier C. Measurement of urinary biomarkers of parabens, benzophenone-3 and phthalates in a Belgian population. Biomed. Res. Int. 2014, ID 649314.
  • Dewalque L., Pirard C., Dubois N., Charlier C. Simultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2014, 949-950:37-47.
  • Dirtu A.C., Geens T., Dirinck E., Malarvannan G., Neels H., Van Gaal L., Jorens P.G., Covaci A. Phthalate metabolites in obese individuals undergoing weight loss: urinary levels and estimation of the phthalates daily intake. Environ. Int. 2013, 59:344-353.
  • Engel S.M., Miodovnik A., Canfield R.L., Zhu C., Silva M.J., Calafat A.M., Wolff M.S. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ. Health Perspect. 2010, 118:565-571.
  • European Food Safety Authorities Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials. EFSA J. 2005, 243:1-20.
  • European Food Safety Authorities Opinion of the scientific panel on food additives, flavourings, processing aids and material in contact with food (AFC) on a request from the commission related to di-butylphthalate (DBP) for use in food contact materials. EFSA J. 2005, 242:1-17.
  • European Food Safety Authorities Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to butylbenzylphthalate (BBP) for use in food contact materials. EFSA J. 2005, 241:1-14.
  • Frederiksen H., Nielsen J.K., Mørck T.A., Hansen P.W., Jensen J.F., Nielsen O., Andersson A.M., Knudsen L.E. Urinary excretion of phthalate metabolites, phenols and parabens in rural and urban Danish mother-child pairs. Int. J. Hyg. Environ. Health 2013, 216:772-783.
  • Frederiksen H., Kranich S.K., Jørgensen N., Taboureau O., Petersen J.H., Andersson A.M. Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-h urine samples: considerations for epidemiological studies. Environ. Sci. Technol. 2013, 47:958-967.
  • Fromme H., Gruber L., Schlummer M., Wolz G., Böhmer S., Angerer J., Mayer R., Liebl B., Bolte G. Intake of phthalates and di(2-ethylhexyl)adipate: results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data. Environ. Int. 2007, 33:1012-1020.
  • Fromme H., Bolte G., Koch H.M., Angerer J., Boehmer S., Drexler H., Mayer R., Liebl B. Occurrence and daily variation of phthalate metabolites in the urine of an adult population. Int. J. Hyg. Environ. Health 2007, 210:21-33.
  • Fromme H., Gruber L., Schuster R., Schlummer M., Kiranoglu M., Bolte G., Völkel W. Phthalate and di-(2-ethylhexyl) adipate (DEHA) intake by German infants based on the results of a duplicate diet study and biomonitoring data (INES 2). Food Chem. Toxicol. 2013, 53:272-280.
  • Fromme H., Lahrz T., Kraft M., Fembacher L., Dietrich S., Sievering S., Burghardt R., Schuster R., Bolte G., Völkel W. Phthalates in German daycare centers: occurrence in air and dust and the excretion of their metabolites by children (LUPE 3). Environ. Int. 2013, 61:64-72.
  • Gray L.E., Ostby J., Furr J., Price M., Veeramachaneni D.N., Parks L. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Sci. 2000, 58:350-365.
  • Guo Y., Wu Q., Kannan K. Phthalate metabolites in urine from China, and implications for human exposures. Environ. Int. 2011, 37:893-898.
  • Hauser R., Meeker J.D., Duty S., Silva M.J., Calafat A.M. Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites. Epidemiology 2006, 17:682-691.
  • Hauser R., Meeker J.D., Singh N.P., Silva M.J., Ryan L., Duty S., Calafat A.M. DNA damage in human sperm is related to urinary levels of phthalate monoester and oxidative metabolites. Hum. Reprod. 2007, 22:688-695.
  • Howdeshell K.L., Wilson V.S., Furr J., Lambright C.R., Rider C.V., Blystone C.R., Hotchkiss A.K., Gray L.E. A mixture of five phthalate esters inhibits fetal testicular testosterone production in the Sprague-Dawley rat in a cumulative, dose-additive manner. Toxicol. Sci. 2008, 105:153-165.
  • Janjua N.R., Frederiksen H., Skakkebaek N.E., Wulf H.C., Andersson A.M. Urinary excretion of phthalates and paraben after repeated whole-body topical application in humans. Int. J. Androl. 2008, 31:118-130.
  • Joensen U.N., Frederiksen H., Jensen M.B., Lauritsen M.P., Olesen I.A., Lassen T.H., Andersson A.M., Jørgensen N. Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men. Environ. Health Perspect. 2012, 120:1397-1403.
  • Kim S., Kang S., Lee G., Lee S., Jo A., Kwak K., Kim D., Koh D., Kho Y.L., Kim S., Choi K. Urinary phthalate metabolites among elementary school children of Korea: sources, risks, and their association with oxidative stress marker. Sci. Total Environ. 2014, 472:49-55.
  • Koch H.M., Drexler H., Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int. J. Hyg. Environ. Health 2003, 206:77-83.
  • Koch H.M., Bolt H.M., Angerer J. Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP. Arch. Toxicol. 2004, 78:123-130.
  • Koch H.M., Bolt H.M., Preuss R., Angerer J. New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP. Arch. Toxicol. 2005, 79:367-376.
  • Koch H.M., Müller J., Wittassek M., Angerer J. Influence of Alimentary Abstinence on Body Burden to Phthalates 2006.
  • Koch H.M., Becker K., Wittassek M., Seiwert M., Angerer J., Kolossa-Gehring M. Di-n-butylphthalate and butylbenzylphthalate - urinary metabolite levels and estimated daily intakes: pilot study for the German Environmental Survey on children. J. Exp. Sci. Environ. Epidemiol. 2007, 17:378-387.
  • Koch H.M., Wittassek M., Brüning T., Angerer J., Heudorf U. Exposure to phthalates in 5-6 years old primary school starters in Germany - a human biomonitoring study and a cumulative risk assessment. Int. J. Hyg. Environ. Health 2011, 214:188-195.
  • Koch H.M., Christensen K.L., Harth V., Lorber M., Brüning T. Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) metabolism in a human volunteer after single oral doses. Arch. Toxicol. 2012, 86:1829-1839.
  • Kohn M.C., Parham F., Masten S.A., Portier C.J., Shelby M.D., Brock J.W., Needham L.L. Human exposure estimates for phthalates. Environ. Health Perspect. 2000, 108:A440-A442.
  • Kortenkamp A., Faust M. Combined exposures to anti-androgenic chemicals: steps towards cumulative risk assessment. Int. J. Androl. 2010, 33:463-474.
  • Kranich S.K., Frederiksen H., Andersson A.M., Jørgensen N. Estimated daily intake and hazard quotients and indices of phthtalate diesters for young danish men. Environ. Sci. Technol. 2014, 48:706-712.
  • Langer S., Bekö G., Weschler C.J., Brive L.M., Toftum J., Callesen M., Clausen G. Phthalate metabolites in urine samples from Danish children and correlations with phthalates in dust samples from their homes and daycare centers. Int. J. Hyg. Environ. Health 2014, 217:78-87.
  • Lin S., Ku H.Y., Su P.H., Chen J.W., Huang P.C., Angerer J., Wang S.L. Phthalate exposure in pregnant women and their children in central Taiwan. Chemosphere 2011, 82:947-955.
  • Luccio-Camelo D.C., Prins G.S. Disruption of androgen receptor signaling in males by environmental chemicals. J. Steroid Biochem. Mol. Biol. 2011, 127:74-82.
  • National Research Council Phthalates and cumulative risk assessment. The Tasks Ahead 2008, The National Academies Press, Washington, DC.
  • Perucca J., Bouby N., Valeix P., Bankir L. Sex difference in urine concentration across differing ages, sodium intake, and level of kidney disease. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 292:R700-R705.
  • Pirard C., Sagot C., Deville M., Dubois N., Charlier C. Urinary levels of bisphenol A, triclosan and 4-nonylphenol in a general Belgian population. Environ. Int. 2012, 48:78-83.
  • Remer T., Fonteyn N., Alexy U., Berkemeyer S. Longitudinal examination of 24-h urinary iodine excretion in schoolchildren as a sensitive, hydration status-independent research tool for studying iodine status. Am. J. Clin. Nutr. 2006, 83:639-646.
  • Sioen I., Fierens T., Van Holderbeke M., Geerts L., Bellemans M., De Maeyer M., Servaes K., Vanermen G., Boon P.E., De Henauw S. Phthalates dietary exposure and food sources for Belgian preschool children and adults. Environ. Int. 2012, 48:102-108.
  • Søeborg T., Frederiksen H., Andersson A.M. Cumulative risk assessment of phthalate exposure of Danish children and adolescents using the hazard index approach. Int. J. Androl. 2012, 35:245-252.
  • Søeborg T., Frederiksen H., Andersson A.M. Considerations for estimating daily intake values of non-persistent environmental endocrine disruptors based on urinary biomonitoring data. Reproduction 2013, 147:455-463.
  • Song N.R., On J.W., Lee J., Park J.D., Kwon H.J., Yoon H.J., Pyo H. Biomonitoring of urinary di(2-ethylhexyl) phthalate metabolites of mother and child pairs in South Korea. Environ. Int. 2013, 54:65-73.
  • Stahlhut R.W., Van Wijngaarden E., Dye T.D., Cook S., Swan S.H. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult US males. Environ. Health Perspect. 2007, 115:876-882.
  • Suzuki Y., Niwa M., Yoshinaga J., Watanabe C., Mizumoto Y., Serizawa S., Shiraishi H. Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis. Environ. Health Prev. Med. 2009, 14:180-187.
  • Swan S.H., Main K.M., Liu F., Stewart S.L., Kruse R.L., Calafat A.M., Mao C.S., Redmon J.B., Ternand C.L., Sullivan S., Teague J.L. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ. Health Perspect. 2005, 113:1056-1061.
  • Swan S.H., Liu F., Hines M., Kruse R.L., Wang C., Redmon J.B., Sparks A., Weiss B. Prenatal phthalate exposure and reduced masculine play in boys. Int. J. Androl. 2010, 33:259-269.
  • US Environmental Protection Agency Risk assessment guidance for superfund: volume I - human health evaluation manual. (Part A) EPA/540/1-89/002. Office of Emergency and Remedial Response 1989, U.S. Environmental Protection Agency, Washington.
  • US Environmental Protection Agency Integrated risk information system (IRIS). Diethyl Phthalate (CASRN 84-66-2) 1993, National Center for Environmental Assessment, Office of Research and Development, Washington, DC, USA, (access 29.01.14). http://www.epa.gov/iris/.
  • Wittassek M., Wiesmüller G.A., Koch H.M., Eckard R., Dobler L., Müller J., Angerer J., Schlüter C. Internal phthalate exposure over the last two decades - a retrospective human biomonitoring study. Int. J. Hyg. Environ. Health 2007, 210:319-333.
  • Wittassek M., Heger W., Koch H.M., Becker K., Angerer J., Kolossa-Gehring M. Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children - a comparison of two estimation models based on urinary DEHP metabolite levels. Int. J. Hyg. Environ. Health 2007, 210:35-42.
  • Wittassek M., Koch H.M., Angerer J., Brüning T. Assessing exposure to phthalates - the human biomonitoring approach. Mol. Nutr. Food Res. 2011, 55:31-37.
  • World Health Organization, Diethyl phthalate. International Programme on Chemical Safety (IPCS), Concise International Chemical Assessment Document 52. , 2003 (access 29.01.14). http://www.who.int/ipcs/publications/cicad/en/cicad52.pdf.
  • Wormuth M., Scheringer M., Vollenweider M., Hungerbühler K. What are the sources of exposure to eight frequently used phthalic acid esters in Europeans?. Risk Anal. 2006, 26:803-824.
  • Zeman F.A., Boudet C., Tack K., Floch Barneaud A., Brochot C., Péry A.R., Oleko A., Vandentorren S. Exposure assessment of phthalates in French pregnant women: results of the ELFE pilot study. Int. J. Hyg. Environ. Health 2013, 216:271-279.
  • Zota A.R., Calafat A.M., Woodruff T.J. Temporal trends in phthalate exposures: findings from the National Health and Nutrition Examination Survey, 2001-2010. Environ. Health Perspect. 2014, 122:235-241.

Similar publications



Contact ORBi