Reference : Fragmentation and isomerization due to field heating in traveling wave ion mobility
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/171487
Fragmentation and isomerization due to field heating in traveling wave ion mobility
English
Morsa, Denis mailto [Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
Gabelica, Valérie mailto [Inserm & Univ. Bordeaux, F-33600, Pessac, France > U869 - ARNA Laboratory, > > > >]
De Pauw, Edwin mailto [Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
2014
Journal of the American Society for Mass Spectrometry
Elsevier Science
25
6
1384-1393
Yes (verified by ORBi)
International
1044-0305
New York
NY
[en] Ion Mobility ; Msss Spectrometry
[en] During their travel inside a traveling wave ion mobility cell (TW IMS), ions are susceptible to heating because of the presence of high intensity electric fields. Here, we report effective temperatures T eff,vib obtained at the injection and inside the mobility cell of a SYNAPT G2 HDMS spectrometer for different probe ions: benzylpyridinium ions and leucine enkephalin. Using standard parameter sets, we obtained a temperature of ~800 K at injection and 728 ± 2 K into the IMS cell for p-methoxybenzylpyridinium. We found that T eff,vib inside the cell was dependent on the separation parameters and on the nature of the analyte. While the mean energy of the Boltzmann distributions increases with ion size, the corresponding temperature decreases because of increasing numbers of vibrational normal modes. We also investigated conformational rearrangements of 7+ ions of cytochrome c and reveal isomerization of the most compact structure, therefore highlighting the effects of weak heating on the gas-phase structure of biologically relevant ions.
Giga-Systems Biology and Chemical Biology
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Denis Morsa Thesis
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/171487
10.1007/s13361-014-0909-9
http://link.springer.com/article/10.1007%2Fs13361-014-0909-9

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