[en] Immunological failure is identified from the estimation of certain parameters of a mathematical model of the HIV infection dynamics. This identification is supported by clinical research results from an original clinical trial. Standard clinical data were collected from infected patients starting Highly Active Anti-Retroviral Therapy (HAART), just after one month following therapy initiation and were used to carry out the model identification. The early diagnosis is shown to be consistent with the patients monitoring after six months.
Disciplines :
Immunology & infectious disease
Author, co-author :
Moog, Claude
Rivadeneira, Pablo
Stan, Guy-Bart
Brunet, Cécile
Raffi, François
Ferre, Virginie
Costanza, Vicente
Mhawej, Marie-José
Ernst, Damien ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Smart grids
Fonteneau, Raphaël ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
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Ouattara, D.A., Mhawej, M.J., Moog, C.H., (2007) IRCCyN Web Software for the Computation of HIV Infection Parameters, , http://vih.irccyn.ec-nantes.fr
Ouattara, D.A., Mhawej, M.J., Moog, C.H., Clinical tests of therapeutical failures based on mathematical modeling of the HIV infection (2008) IEEE Transactions on Circuits and Systems and IEEE Transactions on Automatic Control, Special Issue on Systems Biology, pp. 230-241. , Joint special issue of
Mhawej, M.J., Apoptosis characterizes immunological failure of HIV infected patients (2009) Control Eng Pract, 17, pp. 798-804
Xia, X., Moog, C.H., Identifiability of nonlinear systems with application to HIV/AIDS models (2003) IEEE Transact Automatic Control, 48 (2), pp. 330-336
