[en] Hemoreactivity of the poly (2-(dimethylamino) ethylmethacrylate) polymer (PDMAEMA) under a free form (thus not as a “PolyElectrolyte Complex”) was assessed. In order to facilitate the in vitro monitoring of this polycation and especially to follow its reactivity blood we have labeled it with fluorescein adopting a new chemical route of synthesis. Unexpectedly, using flow cytometry, this study showed a higher affinity of PDMAEMA for platelets than for red blood cells.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Flebus, Luca ; Université de Liège - ULiège > Centre interfacultaire des biomatériaux (CEIB)
Lombart, François ; Université de Liège - ULiège > Centre interfacultaire des biomatériaux (CEIB)
Martinez, Lucia
Sevrin, Chantal ; Université de Liège - ULiège > Centre interfacultaire des biomatériaux (CEIB)
Grandfils, Christian ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Language :
English
Title :
Study of the specific interaction between Fluorescent PDMAEMA and human Platelets
Publication date :
12 July 2014
Event name :
International Society for Biomedical Polymers and Polymeric Biomaterials
