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What is the current status of chondroitin sulfate and glucosamine for the treatment of knee osteoarthritis?

Henrotin, Yves; Marty, Marc; Mobasheri, Ali

2014 • In Maturitas, 78, p. 184-187

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/169970

DOI
10.1016/j.maturitas.2014.04.015

PubMed
24861964

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Keywords :

Osteoarthritis; Chondroitin; glucosmaine

Abstract :

[en] Chondroitin sulfate and glucosamine sulfate exert beneficial effects on the metabolism of in vitro models of cells derived from synovial joints: chondrocytes, synoviocytes and cells from subchondral bone, all of which are involved in osteoarthritis (OA). They increase type II collagen and proteoglycan synthesis in human articular chondrocytes and are able to reduce the production of some pro-inflammatory mediators and proteases, to reduce the cellular death process, and improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Clinical trials have reported a beneficial effect of chondroitin sulfate and glucosamine sulfate on pain and function. The structure-modifying effects of these compounds have been reported and analyzed in recent meta-analyses. The results for knee OA demonstrate a small but significant reduction in the rate of joint space narrowing. Chondroitin sulfate and glucosamine sulphate are recommended by several guidelines from international societies for the management of knee and hip OA, while others do not recommend these products or recommend only under condition. This comprehensive review clarifies the role of these compounds in the therapeutic arsenal for patients with knee OA

Disciplines :

Rheumatology

Author, co-author :

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartillage (U.R.O.C.)

Marty, Marc

Mobasheri, Ali

Language :

English

Title :

What is the current status of chondroitin sulfate and glucosamine for the treatment of knee osteoarthritis?

Publication date :

2014

Journal title :

Maturitas

ISSN :

0378-5122

eISSN :

1873-4111

Publisher :

Elsevier North Holland Biomedical Press, Limerick, Ireland

Volume :

78

Pages :

184-187

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 July 2014

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676 (2 by ULiège)

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Scopus citations^®

96

Scopus citations^®
without self-citations

93

OpenCitations

83

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