Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.

[en] Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.

Disciplines :

Immunology & infectious disease

Author, co-author :

Gutierrez, Geronimo

Rodriguez, Sabrina M.

De Brogniez, Alix ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.

Gillet, Nicolas ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.

Golime, Ramarao

Burny, Arsène ; Université de Liège - ULiège > Agro Biotech Gembloux

Jaworski, Juan-Pablo

Alvarez, Irene

Vagnoni, Lucas

Trono, Karina

Willems, Luc ; Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.

Language :

English

Title :

Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.

Publication date :

2014

Journal title :

Viruses

eISSN :

1999-4915

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Switzerland

Volume :

Issue :

Pages :

2416-2427

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 June 2014

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