Article (Scientific journals)
Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.
Gutierrez, Geronimo; Rodriguez, Sabrina M.; De Brogniez, Alix et al.
2014In Viruses, 6 (6), p. 2416-2427
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Abstract :
[en] Bovine leukemia virus (BLV) and human T-lymphotropic virus type 1 (HTLV-1) are closely related d-retroviruses that induce hematological diseases. HTLV-1 infects about 15 million people worldwide, mainly in subtropical areas. HTLV-1 induces a wide spectrum of diseases (e.g., HTLV-associated myelopathy/tropical spastic paraparesis) and leukemia/lymphoma (adult T-cell leukemia). Bovine leukemia virus is a major pathogen of cattle, causing important economic losses due to a reduction in production, export limitations and lymphoma-associated death. In the absence of satisfactory treatment for these diseases and besides the prevention of transmission, the best option to reduce the prevalence of d-retroviruses is vaccination. Here, we provide an overview of the different vaccination strategies in the BLV model and outline key parameters required for vaccine efficacy.
Disciplines :
Immunology & infectious disease
Author, co-author :
Gutierrez, Geronimo
Rodriguez, Sabrina M.
De Brogniez, Alix ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Gillet, Nicolas ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Golime, Ramarao
Burny, Arsène ;  Université de Liège - ULiège > Agro Biotech Gembloux
Jaworski, Juan-Pablo
Alvarez, Irene
Vagnoni, Lucas
Trono, Karina
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Biologie cell. et moléc.
Language :
English
Title :
Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm.
Publication date :
2014
Journal title :
Viruses
eISSN :
1999-4915
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Volume :
6
Issue :
6
Pages :
2416-2427
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 June 2014

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