Reference : Importance of clean-up for comparison of TEQ-values obtained by CALUX and chemo-analysis
Scientific journals : Article
Physical, chemical, mathematical & earth Sciences : Chemistry
Importance of clean-up for comparison of TEQ-values obtained by CALUX and chemo-analysis
Van Wouwe, N. [> > > >]
Windal, I. [> > > >]
Vanderperren, H. [> > > >]
Eppe, Gauthier mailto [Université de Liège - ULiège > > Centre interfac. d'analyse des résidus en traces (CART) >]
Xhrouet, Céline mailto [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
De Pauw, Edwin mailto [Université de Liège - ULiège > > Chimie physique, spectrométrie de masse >]
Goeyens, L. [> > > >]
Baeyens, W. [> > > >]
Elsevier Science Bv
Yes (verified by ORBi)
[en] CALUX ; fractionation ; human plasma ; dioxin-like compounds
[en] This paper presents Chemically Activated LUciferine gene eXpression (CALUX) TEQ-values obtained for nine plasma samples following two different purification procedures, one of them involving fractionation. CALUX results obtained for the dioxin (DX) and dioxin + PCB (DX + PCB) fractions were then compared to the GC-HRMS TEQ-values calculated for the 17 polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (17 PCDD/F) and 17 PCDD/F + 4 cPCB congeners, respectively. The overestimation of the CALUX (DX fraction) TEQ-values in comparison with the chemo-analyses of the 17 PCDD/F is mainly explained by the presence of other AhR agonists, like brominated compounds. Otherwise, the constancy of the CALUX (DX + PCB fraction) TEQ-value which compares to increasing the GC-HRMS (17 PCDD/F + 4 cPCB) TEQ results raises questions concerning (1) the significance of CALUX results obtained without fractionation as well as (2) the toxicological effect of a cocktail of contaminants on the human health. (C) 2004 Elsevier B.V. All rights reserved.

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