Article (Scientific journals)
The role of statin treatment in valvular heart disease: is the jury still out?
Antonini-Canterin, Francesco; Mateescu, Anca D.; Nicolosi, Gian Luigi et al.
2013In Acta Cardiologica, 68 (4), p. 403-11
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Keywords :
Chemoprevention/methods; Disease Progression; Heart Valve Diseases/classification/diagnosis/drug therapy/physiopathology; Hemodynamics/drug effects; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Randomized Controlled Trials as Topic
Abstract :
[en] Valvular heart disease (VHD) represents a significant burden within the spectrum of cardiovascular diseases. In recent years, there has been a great interest in finding medical treatments able to slow the progression ofVHD. The negative results of several large randomized trials failing to demonstrate a benefit of such therapies, has led to a decrease of interest in this field. However, finding a medical treatment capable of preventing VHD progression is still a hot topic, due to the important clinical implications. We believe that the jury is still out on the debate about the role of statin therapy in VHD, considering also recently published studies providing new information with future implications for the treatment of this disease process. This article gives an overview of the published evidence about the role of hydroxymethylglutaryl coenzyme-A reductase inhibitors on delaying progressive valve dysfunction. A preventive therapy, which could influence not only the haemodynamic progression of valve disease, but also the cardiovascular outcome, is warranted. Large, prospective, randomized trials are needed to properly evaluate the role of statins in the early stages of valvular heart disease.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Antonini-Canterin, Francesco
Mateescu, Anca D.
Nicolosi, Gian Luigi
Ginghina, Carmen
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie
Cosyns, Bernard
Popescu, Bogdan Alexandru
Language :
English
Title :
The role of statin treatment in valvular heart disease: is the jury still out?
Publication date :
2013
Journal title :
Acta Cardiologica
ISSN :
0001-5385
eISSN :
1784-973X
Publisher :
Association Royale des Sociétés Scientifiques Medicales Belges/Koninklijke Vereniging van de Belgische Medische Wetenschappelijke Genootschappen, Bruxelles, Belgium
Volume :
68
Issue :
4
Pages :
403-11
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 May 2014

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