Article (Scientific journals)
Intermittent bisphosphonate therapy in postmenopausal osteoporosis - Progress to date
Reginster, Jean-Yves; Malaise, Olivier; NEUPREZ, Audrey et al.
2007In Drugs and Aging, 24 (5), p. 351-359
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Abstract :
[en] Bisphosphonates are the most widely prescribed drugs in osteoporosis today. They have unequivocally shown their ability to reduce fracture rate at the spine (alendronic acid, risedronic acid, ibandronic acid) and at the hip (alendronic acid and risedronic acid). However, their dosage and administration procedures and the adverse reactions induced by their oral intake are responsible for low adherence. Therefore, intermittent regimens have been developed. Weekly alendronic acid and risedronic acid provide similar benefits, in terms of bone mineral density (BMD) and changes in biochemical markers, as those seen with their daily formulations. Ibandronic acid has been shown to reduce vertebral fractures when given intermittently. Ibandronic acid given orally monthly and intravenously every 2 or 3 months provides increases in BMD similar to the daily formulation. Yearly intravenous infusions of zoledronic acid are currently being evaluated for their ability to reduce fractures. If the efficacy and safety of bisphosphonates given at administration intervals longer than weekly are confirmed, this might significantly improve patient adherence and long-term outcomes of bisphosphonate treatment in postmenopausal osteoporosis.
Disciplines :
Geriatrics
Pharmacy, pharmacology & toxicology
Sociology & social sciences
Author, co-author :
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Malaise, Olivier ;  Université de Liège - ULiège > Cert.ECG
NEUPREZ, Audrey ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Jouret, V. E.
Close, Pierre;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Intermittent bisphosphonate therapy in postmenopausal osteoporosis - Progress to date
Publication date :
2007
Journal title :
Drugs and Aging
ISSN :
1170-229X
eISSN :
1179-1969
Publisher :
Adis International Ltd, Auckland, New Zealand
Volume :
24
Issue :
5
Pages :
351-359
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 July 2009

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