Article (Scientific journals)
Measurement of PCDDs, PCDFs, and non-ortho-PCBs by comprehensive two-dimensional gas chromatography-isotope dilution time-of-flight mass spectrometry (GC x GC-IDTOFMS)
Focant, Jean-François; Reiner, Eric J.; MacPherson, Karen et al.
2004In Talanta, 63 (5), p. 1231-1240
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Keywords :
polychlorinated dibenzo-p-dioxins (PCDDs); polychlorinated dibenzofurans (PCDFs); coplanar polychlorinated biphenyls (cPCBs); comprehensive two-dimensional gas chromatography (GC x GC); time-of-flight mass spectrometry (TOFMS)
Abstract :
[en] Comprehensive two-dimensional gas chromatography with isotope-dilution time-of-flight mass spectrometry (GC x GC-IDTOFMS) was used to measure polychlorinated dibenzo-p-dioxin (PCDD), polychlorinated dibenzofuran (PCDF), and coplanar polychlorinated biphenyl (cPCB) concentrations in ash, sediment, vegetation, and fish samples. The GC x GC capability was achieved by using a quad jet, dual stage, thermal modulator. Zone compression of the GC peaks from modulation resulted in a significant increase of the signal intensity over classical GC-IDTOFMS. The GC x GC column set used an Rtx-Dioxin 2 phase as the first dimension (D-1) and an Rtx-500 as the second dimension (D-2). The chromatographic separation of the 17 PCDD/Fs and the 4 cPCBs was attained in D-1 except for 2,3,7,8-TCDD and CB126 for which deconvoluted ion currents (DIC) were required to be reported separately. The Rtx-500 phase separated the bulk matrix interfering compounds from the target analytes in D-2. The instrumental limit of detection (iLODs) was 0.5 pg for 2,3,7,8-TCDD. The calibration curves showed good correlation coefficients for all the compounds investigated in the concentration range of 0.5-200 pg. GC x GC-IDTOFMS results compared favorably to those from conventional isotope-dilution one-dimensional gas chromatography-high resolution mass spectrometry (GC-IDHRMS). The comprehensive mass analysis of the TOFMS further permitted the identification of other contaminants of concern in the samples. (C) 2004 Elsevier B.V. All rights reserved.
Disciplines :
Environmental sciences & ecology
Chemistry
Author, co-author :
Focant, Jean-François  ;  Centers for Disease Control and Prevention - CDC > OAT Lab
Reiner, Eric J.;  Ministry of Environment (Ontario, Canada)
MacPherson, Karen;  Ministry of Environment (Ontario, Canada)
Kolic, Terry;  Ministry of Environment (Ontario, Canada)
Sjödin, Andreas;  Centers for Disease Control and Prevention - CDC > OAT Lab
Patterson, Donald G.;  Centers for Disease Control and Prevention - CDC > OAT Lab
Reese, Shawn L.
Dorman, Frank L.
Cochran, Jack
Language :
English
Title :
Measurement of PCDDs, PCDFs, and non-ortho-PCBs by comprehensive two-dimensional gas chromatography-isotope dilution time-of-flight mass spectrometry (GC x GC-IDTOFMS)
Publication date :
08 August 2004
Journal title :
Talanta
ISSN :
0039-9140
eISSN :
1873-3573
Publisher :
Elsevier Science Bv, Amsterdam, Netherlands
Volume :
63
Issue :
5
Pages :
1231-1240
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 July 2009

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