Article (Scientific journals)
Mesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Erpicum, Pauline; DETRY, Olivier; WEEKERS, Laurent et al.
2014In Nephrology Dialysis Transplantation, 29, p. 1487-1493
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Keywords :
acute kidney injury; ischaemia/reperfusion; ischaemic conditioning; kidney transplantation; mesenchymal stromal cells
Abstract :
[en] Acute kidney injury (AKI) represents a worldwide public health issue of increasing incidence, with a significant morbi-mortality. AKI treatment mostly relies on supportive manoeuvres in the absence of specific target-oriented therapy. The pathophysiology of AKI commonly involves ischaemia/reperfusion (I/R) events, which cause both immune and metabolic consequences in renal tissue. Similarly, at the time of kidney transplantation (KT), I/R is an unavoidable event which contributes to early graft dysfunction and enhanced graft immunogenicity. Mesenchymal stromal cells (MSCs) represent a heterogeneous population of adult, fibroblast-like multi-potent cells characterized by their ability to differentiate into tissues of mesodermal lineages. Because MSC have demonstrated immunomodulatory, anti-inflammatory and tissue repair properties, MSC administration at the time of I/R and/or at later times has been hypothesized to attenuate AKI severity and to accelerate the regeneration process. Furthermore, MSC in KT could help prevent both I/R injury and acute rejection, thereby increasing graft function and survival. In this review, summarizing the encouraging observations in animal models and in pilot clinical trials, we outline the benefit of MSC therapy in AKI and KT, and envisage their putative role in renal ischaemic conditioning.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Erpicum, Pauline ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
DETRY, Olivier  ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
WEEKERS, Laurent  ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
BONVOISIN, Catherine ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
LECHANTEUR, Chantal ;  Centre Hospitalier Universitaire de Liège - CHU > Thérapie cellulaire
BRIQUET, Alexandra ;  Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Jouret, François  ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Language :
English
Title :
Mesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion.
Publication date :
2014
Journal title :
Nephrology Dialysis Transplantation
ISSN :
0931-0509
eISSN :
1460-2385
Publisher :
Oxford University Press, United Kingdom
Volume :
29
Pages :
1487-1493
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 20 March 2014

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