Article (Scientific journals)
Myeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis.
Nzeusseu Toukap, A.; Delporte, C.; Noyon, C. et al.
2014In Free Radical Research, 48 (4), p. 461-5
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Keywords :
myeloperoxidase; rheumatoid arthritis; synovial fluid
Abstract :
[en] Abstract Objective. Plasma and synovial myeloperoxidase (MPO) and its products were strongly associated with osteoarthritis (OA) and rheumatoid arthritis (RA). In addition, it is well known that there is a link between oxidative stress and cytokines. The present study aims at investigating the link between synovial MPO (and its products), interleukin (IL)-18, which is involved in the degradation of articular cartilage in RA, and IL-8, which is involved in recruitment and activation of neutrophils during inflammation. Effects of the treatment of RA on the biological parameters were also investigated. Methods. Patients (n = 105) were studied including 39 patients with OA, 33 with RA and 33 with RA receiving a specific treatment. Disease activity score (DAS-28) was calculated whereas MPO antigen/activity, neutrophils, chloro-tyrosine (Cl-Tyr), homocitrulline (Hcit), IL-8, and IL-18 were measured in synovial fluid (SF) and CRP was measured in serum. Results. DAS-28 and CRP levels were not significantly different between groups. MPO activity, and MPO, Cl-Tyr, and Hcit levels were significantly higher in SF of RA patients than OA patients. MPO specific activity (MPO activity/antigen ratio) was significantly lower in treated than in untreated RA patients as was IL-8. MPO activity and concentration were correlated with IL-8 and IL-18 in untreated but not in treated RA patients. Conclusions. MPO level is related to IL-8 and IL-18 levels in untreated RA patients. A link has been shown between treatment and decrease of IL-8, MPO specific activity and Hcit in SF. The causal role of MPO in SF inflammation and how treatment can affect MPO specific activity need further investigations.
Research center :
CORD - Centre de l'Oxygène, Recherche et Développement - ULiège
Disciplines :
Immunology & infectious disease
Author, co-author :
Nzeusseu Toukap, A.;  Université Catholique de Louvain - UCL
Delporte, C.;  Université Libre de Bruxelles - ULB
Noyon, C.;  Université Libre de Bruxelles - ULB
Franck, Thierry  ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Rousseau, A.;  Université Libre de Bruxelles - ULB
Serteyn, Didier  ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Raes, M.;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP
Vanhaeverbeek, M.;  Université Libre de Bruxelles - ULB
Moguilevsky, N.;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP
Neve, J.;  Université Libre de Bruxelles - ULB
Vanhamme, L.;  Université Libre de Bruxelles - ULB
Durez, P.;  Université Catholique de Louvain - UCL
Van Antwerpen;  Université Libre de Bruxelles - ULB
Zouaoui Boudjeltia, K.;  Université Libre de Bruxelles - ULB
More authors (4 more) Less
Language :
English
Title :
Myeloperoxidase and its products in synovial fluid of patients with treated or untreated rheumatoid arthritis.
Publication date :
2014
Journal title :
Free Radical Research
ISSN :
1071-5762
eISSN :
1029-2470
Publisher :
Taylor & Francis, United Kingdom
Volume :
48
Issue :
4
Pages :
461-5
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 March 2014

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