Reference : A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with ...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/164026
A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with major effect on IgA concentration in bovine milk.
English
Berry, Sarah [ViaLactia Biosciences, Auckland, New Zealand > > > >]
Coppieters, Wouter mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Davis, Stephen [ViaLactia Biosciences, Auckland, New Zealand > > > >]
Burrett, Alayna [ViaLactia Biosciences, Auckland, New Zealand > > > >]
Thomas, Natalie [ViaLactia Biosciences, Auckland, New Zealand > > > >]
Palmer, David [School of Biological Sciences, University of Auckland, Auckland, New Zealand, > > > >]
Kelly, Van [School of Biological Sciences, University of Auckland, Auckland, New Zealand, > > > >]
Obolonkin, Vladimir [Livestock Improvement Corporation, Hamilton, New Zealand > > > >]
Sanders, Kathryn [Livestock Improvement Corporation, Hamilton, New Zealand > > > >]
Spelman, Richard [Livestock Improvement Corporation, Hamilton, New Zealand > > > >]
Georges, Michel mailto [Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale >]
Lehnert, Klaus [ViaLactia Biosciences, Auckland, New Zealand > > > >]
Snell, Russell [School of Biological Sciences, University of Auckland, Auckland, New Zealand, > > > >]
Mar-2013
PLoS ONE
8
3
e57219
Yes (verified by ORBi)
International
1932-6203
United States
[en] Animals ; Cattle ; Chromosome Mapping ; Chromosomes, Mammalian ; Colostrum/chemistry ; Female ; Gene Expression ; Genetic Association Studies ; Genotype ; Haplotypes ; Immunoglobulin A/analysis/metabolism ; Liver/metabolism/pathology ; Milk/chemistry ; Phenotype ; Quantitative Trait Loci ; Receptors, Polymeric Immunoglobulin/genetics/metabolism ; Secretory Component/genetics/metabolism
[en] The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide significant QTL on chromosome 16, maximising at 4.8 Mbp. The polymeric immunoglobulin receptor gene (PIGR) was within the confidence interval of the QTL. In addition, mRNA expression analysis revealed a liver PIGR expression QTL mapping to the same locus as the IgA quantitative trait locus. Sequencing and subsequent genotyping of the PIGR gene revealed three divergent haplotypes that explained the variance of both the IgA QTL and the PIGR expression QTL. Genetic selection based on these markers will facilitate the production of bovine herds producing milk with higher concentrations of IgA.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/164026
10.1371/journal.pone.0057219

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
berry_2013.pdfPublisher postprint871.79 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.