Article (Scientific journals)
A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with major effect on IgA concentration in bovine milk.
Berry, Sarah; Coppieters, Wouter; Davis, Stephen et al.
2013In PLoS ONE, 8 (3), p. 57219
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Keywords :
Animals; Cattle; Chromosome Mapping; Chromosomes, Mammalian; Colostrum/chemistry; Female; Gene Expression; Genetic Association Studies; Genotype; Haplotypes; Immunoglobulin A/analysis/metabolism; Liver/metabolism/pathology; Milk/chemistry; Phenotype; Quantitative Trait Loci; Receptors, Polymeric Immunoglobulin/genetics/metabolism; Secretory Component/genetics/metabolism
Abstract :
[en] The aim of this study was to determine a genetic basis for IgA concentration in milk of Bos taurus. We used a Holstein-Friesian x Jersey F2 crossbred pedigree to undertake a genome-wide search for QTL influencing IgA concentration and yield in colostrum and milk. We identified a single genome-wide significant QTL on chromosome 16, maximising at 4.8 Mbp. The polymeric immunoglobulin receptor gene (PIGR) was within the confidence interval of the QTL. In addition, mRNA expression analysis revealed a liver PIGR expression QTL mapping to the same locus as the IgA quantitative trait locus. Sequencing and subsequent genotyping of the PIGR gene revealed three divergent haplotypes that explained the variance of both the IgA QTL and the PIGR expression QTL. Genetic selection based on these markers will facilitate the production of bovine herds producing milk with higher concentrations of IgA.
Disciplines :
Genetics & genetic processes
Author, co-author :
Berry, Sarah;  ViaLactia Biosciences, Auckland, New Zealand
Coppieters, Wouter ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Davis, Stephen;  ViaLactia Biosciences, Auckland, New Zealand
Burrett, Alayna;  ViaLactia Biosciences, Auckland, New Zealand
Thomas, Natalie;  ViaLactia Biosciences, Auckland, New Zealand
Palmer, David;  School of Biological Sciences, University of Auckland, Auckland, New Zealand,
Kelly, Van;  School of Biological Sciences, University of Auckland, Auckland, New Zealand,
Obolonkin, Vladimir;  Livestock Improvement Corporation, Hamilton, New Zealand
Sanders, Kathryn;  Livestock Improvement Corporation, Hamilton, New Zealand
Spelman, Richard;  Livestock Improvement Corporation, Hamilton, New Zealand
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Lehnert, Klaus;  ViaLactia Biosciences, Auckland, New Zealand
Snell, Russell;  School of Biological Sciences, University of Auckland, Auckland, New Zealand,
More authors (3 more) Less
Language :
English
Title :
A triad of highly divergent polymeric immunoglobulin receptor (PIGR) haplotypes with major effect on IgA concentration in bovine milk.
Publication date :
March 2013
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, United States - California
Volume :
8
Issue :
3
Pages :
e57219
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 March 2014

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