Article (Scientific journals)
A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock
Kumar Kadri, Naveen; Sahana, Goutam; Charlier, Carole et al.
2014In PLoS Genetics, 10 (1), p. 1004049
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Abstract :
[en] In dairy cattle, the widespread use of artificial insemination has resulted in increased selection intensity, which has led to spectacular increase in productivity. However, cow fertility has concomitantly severely declined. It is generally assumed that this reduction is primarily due to the negative energy balance of high-producing cows at the peak of lactation. We herein describe the fine-mapping of a major fertility QTL in Nordic Red cattle, and identify a 660-kb deletion encompassing four genes as the causative variant. We show that the deletion is a recessive embryonically lethal mutation. This probably results from the loss of RNASEH2B, which is known to cause embryonic death in mice. Despite its dramatic effect on fertility, 13%, 23% and 32% of the animals carry the deletion in Danish, Swedish and Finnish Red Cattle, respectively. To explain this, we searched for favorable effects on other traits and found that the deletion has strong positive effects on milk yield. This study demonstrates that embryonic lethal mutations account for a non-negligible fraction of the decline in fertility of domestic cattle, and that associated positive effects on milk yield may account for part of the negative genetic correlation. Our study adds to the evidence that structural variants contribute to animal phenotypic variation, and that balancing selection might be more common in livestock species than previously appreciated.
Research center :
Unit of Animal Genomics - GIGA-R
Center for Quantitative Genetics and Genomics - Aarhus University
MTT Agrifood Research Finland, Biotechnology and Food Research, Jokioinen, Finland
Disciplines :
Animal production & animal husbandry
Author, co-author :
Kumar Kadri, Naveen;  Aarhus University > Department of Molecular Biology and Genetics > Center for Quantitative Genetics and Genomics
Sahana, Goutam;  Aarhus University > Department of Molecular Biology and Genetics > Center for Quantitative Genetics and Genomics
Charlier, Carole  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Iso-Touru, Tehri;  MTT Agrifood Research Finland > Biotechnology and Food Research
Guldbrandtsen, Bernt;  Aarhus University > Department of Molecular Biology and Genetics > Center for Quantitative Genetics and Genomics
Karim, Latifa ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Sander Nielsen, Ulrik;  Danish Agricultural Advisory Service, Aarhus N, Denmark
Panitz, Frank;  Aarhus University > Department of Molecular Biology and Genetics > Molecular Genetics and Systems Biology
Pedersen Aamand, Gert;  Nordic Cattle Genetic Evaluation, Aarhus N, Denmark
Schulman, Nina;  MTT Agrifood Research Finland > Biotechnology and Food Research
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Vilkki, Johanna;  MTT Agrifood Research Finland > Biotechnology and Food Research
Sandø Lund, Mogens;  Aarhus University > Department of Molecular Biology and Genetics > Center for Quantitative Genetics and Genomics
Druet, Tom ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
More authors (4 more) Less
Language :
English
Title :
A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock
Publication date :
January 2014
Journal title :
PLoS Genetics
ISSN :
1553-7390
eISSN :
1553-7404
Publisher :
Public Library of Science, San Francisco, United States - California
Volume :
10
Issue :
1
Pages :
e1004049
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Genomic Selection
Funders :
Danish Directorate for Food, Fisheries and Agri Business, VikingGenetics, Nordic Cattle Genetic Evaluation, and Aarhus University.Walloon Direction Générale Opérationnelle Agriculture, Ressources naturelles et Environnement ‘DGARNE’ (grants D31-1271 and D31-1272). MG is funded by the European Research Council (ERC-DAMONA) and by the Walloon DGARNE.
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