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Article (Scientific journals)
Simultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry
Dewalque, Lucas; PIRARD, Catherine; DUBOIS, Nathalie et al.
2014 • In Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 949-950, p. 37-47
Peer Reviewed verified by ORBi
Permalink
https://hdl.handle.net/2268/161527
DOI
10.1016/j.jchromb.2014.01.002
PubMed
24463399
 

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J Chrom B - Simultaneous determination of some phthalate metabolites parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry.pdf
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Keywords :
parabens; phthalate metabolites; benzophenone-3; urine; LC-MS-MS
Abstract :
[en] Phthalates, parabens and 2-hydroxy-4-methoxybenzophenone or benzophone-3 are thought to act as endocrine disrupting chemicals, being able to disrupt the endocrine balance and therefore able to lead to some hormonal diseases. Numerous large-scale biomonitoring studies have detected the biomarkers of these compounds in more than 75% of the general population. To assess the exposure to these chemicals, we developed an analytical method based on a Solid Phase Extraction (SPE) prior to ultra high pressure liquid chromatographytandem mass spectrometry (UPLC-MS/MS) for the simultaneous measurement of seven phthalate metabolites (monobenzyl phthalate, mono-n-butyl phthalate, mono-iso-butyl phthalate, mono-2-ethylhexyl phthalate, mono-2-ethyl-5-hydroxyhexyl phthalate, mono-2- ethyl-5-oxohexyl phthalate, monoethyl phthalate), four parabens (methyl paraben, ethyl paraben, n-propyl paraben, n-butyl parabens) and benzophenone-3 in human urine. The distinction between unconjugated, glucuro- and sulfoconjugated forms was achieved using different enzymatic hydrolyses. The whole procedure was validated according to the total error approach, and was demonstrated to be linear (regression coefficient ranging from 0.987 to 0.998) and accurate (inter and intra assay precision <17.71%, relative bias <5.87%) in the dosing range of concentrations. The limits of quantification (LOQs) obtained ranged between 0.30 and 1.23 ng/ml depending on the analyte. The reliability of the method was proven in passing successfully the German External Quality Assessment Scheme (G-EQUAS). Moreover, the urine from 25 volunteers were analyzed for the determination of glucuro-, sulfo- and free species separately. Phthalate metabolites, parabens and benzophenone-3 were positively detected in almost all urine samples, with detection rates ranging from 40 to 100%. Levels measured ranged from
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Dewalque, Lucas ;  Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
PIRARD, Catherine  ;  Centre Hospitalier Universitaire de Liège - CHU > Toxicologie clinique
DUBOIS, Nathalie ;  Centre Hospitalier Universitaire de Liège - CHU > Toxicologie clinique
Charlier, Corinne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
Language :
English
Title :
Simultaneous determination of some phthalate metabolites, parabens and benzophenone-3 in urine by ultra high pressure liquid chromatography tandem mass spectrometry
Publication date :
2014
Journal title :
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
ISSN :
1570-0232
eISSN :
1873-376X
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
949-950
Pages :
37-47
Peer reviewed :
Peer Reviewed verified by ORBi
Additional URL :
http://www.sciencedirect.com/science/article/pii/S157002321400004X#
Available on ORBi :
since 20 January 2014

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