Reference : Mast cells: potential positive and negative roles in tumor biology.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Life sciences : Biochemistry, biophysics & molecular biology
Mast cells: potential positive and negative roles in tumor biology.
Marichal, Thomas mailto [Université de Liège - ULiège > > GIGA-Research >]
Tsai, Mindy []
Galli, Stephen J. []
Cancer Immunology Research
Yes (verified by ORBi)
[en] mast cell ; tumor ; angiogenesis
[en] Mast cells are immune cells that reside in virtually all vascularized tissues. Upon activation by diverse mechanisms, mast cells can secrete a broad array of biologically active products that either are stored in the cytoplasmic granules of the cells (e.g., histamine, heparin, various proteases) or are produced de novo upon cell stimulation (e.g., prostaglandins, leukotrienes, cytokines, chemokines, and growth factors). Mast cells are best known for their effector functions during anaphylaxis and acute IgE-associated allergic reactions, but they also have been implicated in a wide variety of processes that maintain health or contribute to disease. There has been particular interest in the possible roles of mast cells in tumor biology. In vitro studies have shown that mast cells have the potential to influence many aspects of tumor biology, including tumor development, tumor-induced angiogenesis, and tissue remodeling, and the shaping of adaptive immune responses to tumors. Yet, the actual contributions of mast cells to tumor biology in vivo remain controversial. Here, we review some basic features of mast cell biology with a special emphasis on those relevant to their potential roles in tumors. We discuss how using in vivo tumor models in combination with models in which mast cell function can be modulated has implicated mast cells in the regulation of host responses to tumors. Finally, we summarize data from studies of human tumors that suggest either beneficial or detrimental roles for mast cells in tumors.
FP7 ; 299954 - MAST CELLS IN ECZEMA - Study of the role of mast cells in the modulation of immune and inflammatory responses associated with eczema: novel genetic approaches from mouse systems and relevance to the human disease.

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