A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom.

[en] Allergies are widely considered to be misdirected type 2 immune responses, in which immunoglobulin E (IgE) antibodies are produced against any of a broad range of seemingly harmless antigens. However, components of insect venoms also can sensitize individuals to develop severe IgE-associated allergic reactions, including fatal anaphylaxis, upon subsequent venom exposure. We found that mice injected with amounts of honeybee venom similar to that which could be delivered in one or two stings developed a specific type 2 immune response that increased their resistance to subsequent challenge with potentially lethal amounts of the venom. Our data indicate that IgE antibodies and the high affinity IgE receptor, FcepsilonRI, were essential for such acquired resistance to honeybee venom. The evidence that IgE-dependent immune responses against venom can enhance survival in mice supports the hypothesis that IgE, which also contributes to allergic disorders, has an important function in protection of the host against noxious substances.

Disciplines :

Life sciences: Multidisciplinary, general & others

Author, co-author :

Marichal, Thomas ; Université de Liège - ULiège > GIGA-Research

Starkl, Philipp

Reber, Laurent L.

Kalesnikoff, Janet

Oettgen, Hans C.

Tsai, Mindy

Metz, Martin

Galli, Stephen J.

Language :

English

Title :

A Beneficial Role for Immunoglobulin E in Host Defense against Honeybee Venom.

Publication date :

2013

Journal title :

Immunity

ISSN :

1074-7613

eISSN :

1097-4180

Publisher :

Cell Press, United States - Massachusetts

Volume :

Issue :

Pages :

963-75

Peer reviewed :

Peer Reviewed verified by ORBi

European Projects :

FP7 - 299954 - MAST CELLS IN ECZEMA - Study of the role of mast cells in the modulation of immune and inflammatory responses associated with eczema: novel genetic approaches from mouse systems and relevance to the human disease.

Funders :

CE - Commission Européenne [BE]

Commentary :

Available on ORBi :

since 25 December 2013

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116

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135

Bibliography

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