Body Weight/drug effects/physiology; Fatty Acids, Omega-3/blood/pharmacology; Female; Humans; Linear Models; Male; Middle Aged; Obesity/blood; Phospholipids/blood/chemistry; Prospective Studies
Abstract :
[en] OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.
Disciplines :
Human health sciences: Multidisciplinary, general & others
Author, co-author :
Jakobsen, Marianne U.
Dethlefsen, Claus
Due, Karen M.
Slimani, Nadia
Chajes, Veronique
May, Anne M.
Sorensen, Thorkild I. A.
Halkjaer, Jytte
Tjonneland, Anne
Clavel-Chapelon, Francoise
Boutron-Ruault, Marie-Christine
Fagherazzi, Guy
Teucher, Birgit
Kaaks, Rudolf
Boeing, Heiner
Schutze, Madlen
Trichopoulou, Antonia
Zylis, Dimosthenis
Makrygiannis, Georgios ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
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