Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change.

Body Weight/drug effects/physiology; Fatty Acids, Omega-3/blood/pharmacology; Female; Humans; Linear Models; Male; Middle Aged; Obesity/blood; Phospholipids/blood/chemistry; Prospective Studies

Abstract :

[en] OBJECTIVE: We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers. METHOD: A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression. RESULTS: The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different. CONCLUSION: The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.

Disciplines :

Human health sciences: Multidisciplinary, general & others

Author, co-author :

Jakobsen, Marianne U.

Dethlefsen, Claus

Due, Karen M.

Slimani, Nadia

Chajes, Veronique

May, Anne M.

Sorensen, Thorkild I. A.

Halkjaer, Jytte

Tjonneland, Anne

Clavel-Chapelon, Francoise

More authors (31 more)

Language :

English

Title :

Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change.

Publication date :

2011

Journal title :

Obesity Facts

ISSN :

1662-4025

eISSN :

1662-4033

Publisher :

Karger, Basel, Switzerland

Volume :

Issue :

Pages :

312-8

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 20 December 2013

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