Reference : Concurrent Synaptic and Systems Memory Consolidation during Sleep
Scientific journals : Article
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/158985
Concurrent Synaptic and Systems Memory Consolidation during Sleep
English
Mascetti, Laura [Université de Liège - ULiège > Centre de Recherches du Cyclotron > > >]
Foret, Ariane [Université de Liège - ULiège > Centre de Recherches du Cyclotron > > >]
Schrouff, Jessica mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Muto, Vincenzo [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
DIDEBERG, Vinciane [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Balteau, Evelyne [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Degueldre, Christian [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Phillips, Christophe [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Luxen, André [Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse >]
Collette, Fabienne [Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie >]
BOURS, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
MAQUET, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
2013
Journal of Neuroscience
Society for Neuroscience
33
24
10182-10190
Yes (verified by ORBi)
International
0270-6474
1529-2401
Washington
DC
[en] memory consolidation ; sleep ; EEG
[en] Memories are consolidated during sleep by two apparently antagonistic processes: (1) reinforcement of memory-specific cortical interactions and (2) homeostatic reduction in synaptic efficiency. Using fMRI, we assessed whether episodic memories are processed during sleep by either or both mechanisms, by comparing recollection before and after sleep. We probed whether LTP influences these processes by contrasting two groups of individuals prospectively recruited based on BDNF rs6265 (Val66Met) polymorphism. Between immediate retrieval and delayed testing scheduled after sleep, responses to recollection increased significantly more in Val/Val individuals than in Met carriers in parietal and occipital areas not previously engaged in retrieval, consistent with “systems-level consolidation.” Responses also increased differentially between allelic groups in regions already activated before sleep but only in proportion to slow oscillation power, in keeping with “synaptic downscaling.” Episodic memories seem processed at both synaptic and systemic levels during sleep by mechanisms involving LTP.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; Université de Liège ; Queen Elisabeth Medical Foundation ; Léon Fredericq Foundation ; Belgian Inter University Attraction Program ; Walloon Excellence in Life Sciences and Biotechnology program
http://hdl.handle.net/2268/158985
10.1523/JNEUROSCI.0284-13.2013

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