Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus)

Spano, L.; Tyler, C. R.; van Aerle, R.; Devos, P.; Mandiki, S. N. M.; Silvestre, F.; Thomé, Jean-Pierre; Kestemont, P.

doi:10.1016/j.aquatox.2003.10.009

Article (Scientific journals)

Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus)

Spano, L.; Tyler, C. R.; van Aerle, R. et al.

2004 • In Aquatic Toxicology, 66 (4), p. 369-379

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https://hdl.handle.net/2268/158975

DOI
10.1016/j.aquatox.2003.10.009

PubMed
15168945

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Keywords :

atrazine; Carassius auratus; endocrine disruption; sex steroids

Abstract :

[en] Sexually mature goldfish (Carassius auratus) of both sexes were exposed to two doses (100 and 1000 mug/l) of the widely used herbicide atrazine (2-chloro-4-ethylamino-6-isolropylamino-s-triazine) for a period of 21 days and effects on the concentrations of gonad and plasma sex steroids (testosterone (T), 17beta-estradiol (E2) and 11-ketotestosterone (11-KT)), plasma vitellogenin (VTG) and gonad histo-morphology assessed. Atrazine did not show any obvious estrogenic effect in males, as determined by a lack of vitellogenin induction. There were, however, effects of atrazine on plasma androgen concentrations (androgen dynamics) and tissue (plasma and gonad) estrogen concentrations in male goldfish; exposure to 1000 mug/l atrazine induced suppression in both testosterone and 11-ketotestosterone, and resulted in elevated 17beta-estradiol, after 21 day of exposure. Further, these suppressive effects on plasma androgens and the induction in estrogen were dose- and time-related. The highest atrazine exposure dose induced structural disruption in the testis and both 100 and 1000 mug/l induced elevated levels of atresia in ovaries. (C) 2003 Elsevier B.V. All rights reserved.

Disciplines :

Pharmacy, pharmacology & toxicology
Environmental sciences & ecology
Aquatic sciences & oceanology

Author, co-author :

Spano, L.

Tyler, C. R.

van Aerle, R.

Devos, P.

Mandiki, S. N. M.

Silvestre, F.

Thomé, Jean-Pierre ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Ecologie animale et écotoxicologie

Kestemont, P.

Language :

English

Title :

Effects of atrazine on sex steroid dynamics, plasma vitellogenin concentration and gonad development in adult goldfish (Carassius auratus)

Publication date :

10 March 2004

Journal title :

Aquatic Toxicology

ISSN :

0166-445X

eISSN :

1879-1514

Publisher :

Elsevier Science Bv, Amsterdam, Netherlands

Volume :

Issue :

Pages :

369-379

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 November 2013

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Scopus citations^®

179

Scopus citations^®
without self-citations

172

OpenCitations

140

OpenAlex citations

198

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