Article (Scientific journals)
Development of a Standard Reference Material for Metabolomics Research
Phinney, K; Ballihaut, G; Bedner, M et al.
2013In Analytical Chemistry, 85 (24), p. 11732-11738
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Keywords :
Metabolomics; Standard Reference Material
Abstract :
[en] The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not towards specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.
Disciplines :
Chemistry
Author, co-author :
Phinney, K
Ballihaut, G
Bedner, M
Benford, B. Y.
Camara, J
Christopher, S
Davis, C
Dodder, N
Eppe, Gauthier  ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique
Lang, B
Long, S
Language :
English
Title :
Development of a Standard Reference Material for Metabolomics Research
Publication date :
November 2013
Journal title :
Analytical Chemistry
ISSN :
0003-2700
eISSN :
1520-6882
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Volume :
85
Issue :
24
Pages :
11732-11738
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 November 2013

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